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• Single-cell fungi
• Reproduce by budding
• Very useful organisms
– Baking
– Alcoholic beverages
• Multicellular
• Characterized by long, branching filaments
called hyphae
Candida albicans
• Due to antibiotic therapy, antineoplastics,
or immunosuppressants
• May result in overgrowth and systemic infections
In the mouth:
• Oral candidiasis or thrush
• Newborn infants and immunocompromised patients
Vaginal candidiasis:
• “Yeast infection”
• Pregnancy, diabetes mellitus, oral contraceptives
Systemic
• Examples: amphotericin B, fluconazole,
ketoconazole, itraconazole
Topical
• Examples: clotrimazole, miconazole, nystatin
*renal toxicity
*neurotoxicity: seizures and paresthesias
flucytosine
• nausea, vomiting, anorexia
griseofulvin
• rash, urticaria, headache, nausea, vomiting, anorexia