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Introduction
More than 2.5 billion people are at risk of infections in over 200 countries worldwide. There are probably tens of millions of cases of dengue each year, and at least five hundred thousand cases of DHF with a mortality of about five per cent in most countries. The vast majority of cases, nearly 95 per cent, are among children of less than 15 years of age.
WHO
30 % of DHF patient will become shock and the case fatality rate almost 5 %. Management focused on fluid and prevention of shock Many pearls can guided us for better management but sometimes pittfall a head For better management understanding the clinical course of diseases is important
Dengue Fever
Acute febrile illness with 2-7 days of fever 2 of this following manifestation - headache - retro-orbital pain - myalgia/arthralgia - rash - hemorrhagic manifestation (petechia and (+) TT - Leucopenia
WHO-SEARO
Clinical course
Clinical course
CDC
Laboratory diagnosis
Pearls in diagnosis
In a child with acute onset of high fever: flushed face without coryza, with petechiae and/or positive tourniquet test should suggest the possibility of dengue infection. Additional hepatomegaly (=tenderness) increases the possibility of DHF. WHO-SEARO
pearls in diagnosis
Curigai DHF pada anak dengan panas + hepatomegali pada akhir periode panas : leukopenia, relative lymphocytosis Bila thrombosit mendadak turun dengan kenaikan Ht (20%) dugaan kuat DHF lakukan intervensi segera !
Ismujianto. Pearls and pittfals pada dengue UKK Infeksi dan Pediatri tropik IDAI
Pearls in diagnosis
Serial platelets and HCT determinations for a drop in platelets and rise in HCT, which represent major pathophysiological changes (abnormal haemostatic and plasma leakage), are essential for early diagnosis of DHF. Rising HCT by 20 per cent or more simultaneously with or shortly after a drop in platelet count that occurring before subsidence of fever or onset of shock) reflects significant plasma losses and indicates a need for volume replacement.
WHO-SEARO
Pittfalls in diagnosis
Misdiagnosis - age < 2 years + high fever, diarrhea, convulsion sugested as encephalitis dengue encephalopathy - Older child +fever + abdominal pain has been diagnosed as acute appendicitis or acute pancreatitis Hasil rapid sero negatif palsu pada panas hari ke 2-3
Ismujianto. Pearls and pittfals pada dengue
Pittfals in diagnosis
Diagnosis based on single laboratory test Diagnosis not based on clinical criteria
Management
Consensus 1. Management of DHF/DSS 1.1 No specific antiviral agent is recommended. 1.2 Supportive/Symptomatic treatment is effective and life-saving if given appropriately. 1.3 Prognosis depends on early diagnosis of DHF and early recognition of potential shock cases. 1.4 Early and effective replacement of lost plasma with electrolyte and colloidal solution results in favorable outcome. Plasma substitute is as good as plasma when there is massive leakage. It is the volume expander, not plasma factors that is needed during the period of leakage. Plasma factors or other blood elements are needed only in cases with massive bleeding and severe DIC.
1.5 Serial follow-up of platelets and hematocrit is helpful.in the early recognition of plasma leakage; and if present, fluid replacement is indicated. 1.6 Platelet transfusion as prophylaxis is not recommended. Studies have shown that there is no transfusion was administered or not. There was no difference in the bleeding episodes between the 2 groups either.
management
1.7 Steroids have no benefit, it has been documented by several studies that high dose corticosteroids have no benefit in the management of DHF/DSS. 1.8The use of Vitamin K is of no benefit because bleeding in DHF is due to DIC, thrombocytopenia, and impaired platelet function. The administration of heparin in DHF with prolonged shock with DIC needs further studies. IV Immunoglobulin needs further investigation.
Nimmanitya . Workshop 8. Management of Dengue Hemorrhagic Fever http://www.psmid.org.ph/vol25/vol25num1topic7h.pdfr
Management of fever
- Antipyretic helps in reducing the height of fever, but cannot shorten the duration of fever - antipyretic of choice : paracetamol - aspirin is contraindicated Reyes syndrome - How about ibuprofen and metamizol ?
Pitfall in treatment
No IVFD monitoring - overhydration Pleural effusion, respiratory distress - prolonged volume replacement lung edema, respiratory distress Failure to detect acidosis check blood gas analysisi in severe cases Failure to detect bleeding decrease of Hb and Hct concomittently
Management of shock
Fluid of choice majority of children with DSS can be treated successfully with isotonic crystalloid solutions.
Paediatr Int Child Health. 2012 May; 32(s1): 3942.
Both colloidal solutions are safe in DHF patients with no allergic reaction observed and no interference in renal functions and hemostasis.
J Med Assoc Thai. 2008 Oct;91 Suppl 3:S97-103.
Management of shock
Initial resuscitation with Ringer's lactate is indicated for children with moderately severe dengue shock syndrome. Dextran 70 and 6 percent hydroxyethyl starch perform similarly in children with severe shock, but given the adverse reactions associated with the use of dextran, starch may be preferable for this group.
N Engl J Med. 2005 Sep 1;353(9):877-89.
Management of shock
There is no evidence from RCTs that resuscitation with colloids reduces the risk of death, compared to resuscitation with crystalloids
Cochrane Database Syst Rev. 2012 Jun 13;6.
Dextran 40 is as effective as plasma (maximum dose 30 ml/kg/day), with some advantages. Over-replacement with more volume and/or for longer period of time will cause pulmonary congestion/oedema, particularly when reabsorption of extravasated plasma occurs.