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4/20/2013
Clinical Development
1. 2. 3.
$ 1 Billion to get a drug to market 15 years to develop and get approved 20 year Patent Life = 5 years of protected sales
3. Time Saver
(Extends Patent life)
Stage 1. Novel Target Validation Lead Optimization Pre-Clinical Development Clinical Development
Outcomes
Develop Compound Identify Indication Safety/Tolerability Feasibility
Stats
2 -4 years 75% Failure Rate 10% of cost 1-3 years 80% Failure Rate 15% of cost 1-2 years 67% Failure Rate 25% of cost 6- 8 years 80% Failure Rate 50 % of cost
Product Interactions
nFlow Chemically Aware
2.
3.
nFlow
4.
FDA Approval
5. Sales $$$ Billion Dollar Market
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Stage 2 4
Technology: Database Driven Application that sits on MS SharePoint (Industry leading collaboration tool)
Result Automates Safety/Tolerability/Feasibility modeling and lab data readout Uses Publicly Available data including FDA and Publication sites Identifies Most Viable compounds for targeted indications
Stage 2
Consensus Scoring
Stage 2
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Key Points: Compound Screening and Repositioning, Third party integration, Patented Algorithm
Product Chem4SharePoint Search Genius SharePoint WebPart Company Scigillence Perkin Elmer Accelrys SubStructure Search Yes Yes No Compound Reposition No No No Compound Screening No No No Deficiencies Inefficient, No integration with other products High Priced tag Static searches, inconclusive results
Accelrys
Yes
No
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H3Biomed AMB
ASINEX
In discussions
% 20
80
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POC in non-NNR/CNS pharmaceutical company Acceptance of Grant submissions by NIH and HHS for continued development of product capabilities
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Industry is researching the problem for resolution Large academia pool of computational chemists and biological modelers to pull from Federal Government funding opportunities of this nature to solve the cost, time and success of drug discovery Application goes beyond drugs to auto, biofuel and bioenergy industries
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Name
Position
Experience
CEO/CTO
20 Yrs. IT (Hands on & leadership) Wachovia (Corporate Information Security Manager) Targacept (Sr. Director Information Technology) Former CEO for Startup Internet Caf (90s)
15 years in IT leadership and operations Targacept Womble Carlyle Litera Corp. Masters in Information Systems Innovator of Blue Atom Technology 10 years Development Experience Published 23 years Life Sciences Published Tied to numerous patents
Chandra Holcomb
VP Operations
Software Development
Computationa l Chemistry
Board Chairman
Executive in Targacept for 15 years Former CEO for software development company Experience with start-up companies, venture funding, IPO and acquisitions 4/20/2013
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