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DOSAGE FORM When a drug is prepared in a form suitable for administration, it is called a Dosage form or a drug product or, in a modern term, a Drug delivery system
PRE-HISTORIC PERIODS Chewing leaves and roots of medicinal plants Inhaling soot from the burning of medicinal substances Primitive extracts from plants and animals
Controlled drug delivery-a new concept introduced in 1960s Refers to the precise control of the rate at which a drug dosage is released from a delivery system, ideally in a constant or near constant manner over a longer period of time
Objectives
Reduced
dosing frequency Improving patient compliance Increase duration of effect Maintain constant drug level in blood Reducing side effect by lowering Cmax
Classified as
Osmotic
Based on
Delivering drug that could exercise control on the time of availability and localization of the drug in the body.
Classified as
Targeted
such as
GI targeting of peptide and protein Immunotherapy such as Monoclonal antibodies, Antisense Compounds, Recombinant vaccines and angiogenesis inhibitors.
or modulated drug delivery system also termed as chronotherapeutics i.e. delivering drug based on chronobiology or science of biological rhythm. Self regulated or Feedback Controlled Drug delivery system
Plulsatile
Biosensor pump combinations Closed loop based on self regulating system Closed loop based on microencapsulated secretory cells
Based on
Treating
the cause of disease rather than symptoms. Therapy-Redesign of cells by introducing the therapeutic genes into genetically disabled cells to deliver therapeutic agents made by gene.
Types are
Gene