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• Neoplasm= new growth – Syn: tumor, denoted by suffixing “OMA” to the tissue
from which it arises.
• It persists in the same excessive manner after the cessation of the stimuli
that has evoked the change.
Basic terms
• Metastasis- distant spread of the malignant tumor cells to sites away from the
primary (original) tumor
• Staging is by noting the size of the tumor, its local invasion, and the distant
spread- TNM classification is employed(T- tumor size, N-lymph node
involvement, M- distant metastasis). Based on the gross features.
Types of neoplasms
Based on behavior
– Benign
– Malignant
– Intermediate / Borderline
Based on histogenesis
• Epithelial tissue
Benign- Adenoma- glandular epithelium
Papilloma- squamous epithelium
Malignant- Carcinoma
• Mesenchymal or Connective tissue
Benign – ‘oma’ to the tissue
Bone- Osteoma,
Cartilage- Chondroma
Malignant- Sarcoma
Differences between benign & malignant tumors
Benign Malignant
- Slow growth rate - Rapidly growing
- No invasion & - Invasive into surrounding normal
tissue
- Metastasizes to distant organs
- No metastasis - Poorly circumscribed with
- Encapsulated & well irregular margins
circumscribed - Necrosis is common
- No necrosis - Ulcers are common especially
- No ulceration / rare in the skin and GIT
- High mitotic activity
- Low mitotic activity - Often poor resemblance but
- Histologic resemblance to can be variable. The nuclei are
normal cells of the parent abnormal & appear
organ& normal nuclear hyperchromatic, irregular &
morphology pleomorphic
Fibroadenoma – Benign tumor of the breast- Well circumscribed &
encapsulated
Benign Malignant
(a) They exert pressure on the Malignant tumors encroach and
adjacent tissues
destroy the adjacent structures
(b) Obstruction of the flow of
thus enabling the neoplastic
fluid
cells to penetrate the walls of
(c) Production of hormones
the blood vessels and lymphatic
(d) Transformation into malignant
channels thereby disseminate
tumors
into the distant sites.
Structure of tumors
• Parenchyma
• Stroma
its ability to induce blood vessels to perfuse it. Stroma also contains
prognosis.
• A neoplasm must develop stromal support components if it is to grow
– Rate of apoptosis
Proliferate rapidly under the influence of growth factors, hormones, diet etc
Inheritable cancers
• Cytological examination by :
Studying cells in the body fluids,
Obtaining the cells by scraping or brushing the surface- exfoilative cytology
Aspirating cells from the mass by a needle-aspiration cytology