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Kelsey Carrio, Megan Preovolos Christian Wilbur, Marjan Amiridavani COGS 175 June 1, 2007
Outline
Parasomnias
Parasomnias are disruptive sleep-related disorders that can occur during arousals from REM sleep or partial arousals from Non-REM sleep. Parasomnias include nightmares, night terrors, sleepwalking, confusional arousals and many others.
Nightmare
Scary dream awakens child.
Night Terror
Child awakes only partially, if at all.
Child sits up, thrashes, and may struggle with caregiver. Child may scream, cry or talk aloud. Eyes may be staring ahead, with heart racing. Child is not very aware of caregiver.
Child often remembers dream and may want to talk about it.
Night terrors
A person experiencing a night terror or sleep terror abruptly awakes from sleep in a terrified state. The person may appear to be awake, but is confused and unable to communicate. They do not respond to voices and are difficult to fully awaken. Night terrors last anywhere from a few seconds up to 30 minutes, after which time the person usually lies down and appears to fall back asleep. People who have sleep terrors usually don't remember the events the next morning.
People experiencing sleep terrors may pose dangers to themselves or others because of limb movements. Night terrors are fairly common in children occurring in approximately 5% of them mostly between the ages of three to five.
Spontaneous attack during stage 3 of NREM sleep 2 s of diffuse hypersynchronous high voltage delta wave arousal Brief EEG delta discharge immediately preceding the clinical episode Increased heart rate (shown from EKG)
Genetic Factors
Guilleminault et. al. 2003 - 35% of children with both NT and SDB have at least
1 immediate relative with parasomnia.
Kales et. al. 1980 - 96% had 1 or more relatives in the pedigree with NT
or Sleepwalking.
Owens et. al. 1999 - 60% risk if both parents were affected.
How SDBs?
Sleep fragmentation due to sleepdisordered breathing may elicit an increase in slow-wave sleep as a recovery mechanism. This could be an increased risk factor for night terrors because they occur in stage 3/4 of sleep.
Acute Triggers
Mild increases in psychosocial stress and relative sleep deprivation are known to trigger night terrors in affected individuals. These triggers most likely play a synergistic role in evoking the night terror, and are not the primary source when they
Treatments
Education Behavioral Hypnosis Medication
Educate
Usually occur around same time each night Track timing of night terrors for a couple of nights Fully wake up 15-30 mins before usually occur
After week, stop waking. If terrors return, repeat waking for one more week 90% effective in study of 50 children (Oakey)
Hypnosis
Medication
Tricyclic Antidepressants
Ex: Imipramine, Trazodone Often used as temporary treatment in conjunction with hypnosis Ex: Diazepam Suppress slow-wave (stage 3/4) sleep Disadvantages
Benzodiazepines
Addictive Growth hormone secreted in slow wave sleep Also studies stating DOESNT work (Cooper)
Melatonin Therapy
Neurohormone produced by pineal gland Therapy for sleep-phase onset delay Take controlled release 30 mins before bedtime Study: Abrupt disappearance of parasomnias in 12 year old boy (within 2 days)
-Smits et al.
Pre-cursor of serotonin
Serotonin may cause production of sleep-producing factors Resolves conflict between slow-wave sleep and arousal
Four children, 8-12 yrs old Treatment: 20-60 mg of imipramine at bedtime followed by self-hypnosis Strategy:
Demystify through education Establish prompt control through imipramine Train in self-regulation through self-hypnosis Discontinue medication but continue hypnosis
Conclusion
Unanswered questions
What causes the sudden occurrences to stop? Exact causes and remedies Is it even conscious? Are they aware?
References
Bruni, et al. L-5-Hydroxytryptophan treatment of sleep terrors in children. Eur J Pediatrics. 2004; 163:402-407 Cardoso, Silvia PhD and Sabbatini, Renato PhD Night Terrors www.cerebromente.org.br/.../terror/terror1_i.htm Copyright 1998 by State University of Campinas, Brazil Chiba, A. Circadian Rhythms 4-19-2007 http://www.cogsci.ucsd.edu/~chiba/circadian_rhythms_07.pdf Di Gennaro, et al.Night terrors associated with thalamic lesion Clinical Neurophysiology, Volume 115, Issue 11, November 2004, Pages 2489-2492 Durand , Mark and Jodi A. Mindell. Behavioral intervention for childhood sleep terrors. Behavior Therapy. 1999;40(30): 705-715. Guilleminault C, Palombini L, Pelayo R, Chervin R. Sleepwalking and Sleep Terrors in Prepubertal Children: What Triggers Them? PEDIATRICS Vol. 111 No. 1 January 2003, pp. e17-e25. Haley, Carma. Terror in the Night http://childrentoday.com 1999-2003 iParenting, LLC Kales A, Soldatos CR, Bixler EO, et al. Hereditary factors in sleepwalking and night terrors. Br J Psychiatry. 1980;137:111-118. Kohen, et al. Sleep-terror disorder in children: the role of self-hypnosis in management. American J Clinic of Hypnosis. 1992 April; 34(4):233-244. Lask,B. A novel and non-toxic treatment for night terrors. BMJ 1988; 297(6648):592. Matthews, B and M. Oakey. Triumph over terror. BR Med Journal. 1986; 292:203. Not Such Sweet Dreams http://www.talaris.org/spotlight_dream.htm Talaris Research Institute 2005 Owens J, Millman R, Spirito A. Sleep Terrors in a Five Year-old Girl. Arch Pediatr Adolesc Med. 1999;153:309-312. Owens J, Spirito A, Nobile C, Arrigan M. Incidence of parasomnias in children with obstructive sleep apnea. Sleep. 1997;20:1193-1196. Rosen, et al. Sleep walking, confusional arousals and sleep terrors in the child. Principles and Practice of Sleep Medicine in the Child. Philadelphia, PA: Saunders. P 99-106. Sleep Disorders: Parasomnias www.webmd.com/sleep-disorders/guide/parasomnias 2005-2007 WebMD, Inc