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UMAR AHMAD MODERATOR: PROF. DR. FAUZIAH OTHMAN Department of Human Anatomy Faculty of Medicine & Health Sciences Universiti Putra Malaysia.
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(receptors)
Hormone delivery
Synapse
(Neurosecretion)
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Endocrine system
Pituitary (hypophysis) Anterior pituitary Posterior pituitary Adrenal gland (suprarenal) Adrenal cortex Adrenal medulla Thyroid gland Follicles Parafollicular cells Parathyroid gland Considered in other lectures: Endocrine pancreas Male Female Enteroendocrine
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PITUITARY
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Location of pituitary
US Federal Government
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Pituitary development
Ross and Pawlina. Histology: Text and Atlas, 5th ed, 2006, fig 21.4, pg 690
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Pituitary nomenclature
Pituitary nomenclature
Umar Ahmad Please also see Ross and Pawlina. Histology: Text 7
and Atlas, 5th ed, 2006, fig 21.3b, pg 689
Acidophil Somatotrope
Acidophil Mammotrope Prolactin (PRL) = lactotrope Basophil Thyrotrope Thyroid stimulating hormone (TSH) = thyrotropin
Basophil
Gonadotrope Luteinizing hormone GnRH (+) (LH), follicle stimulating hormone (FSH); both = gonadotropin Corticotrope Adrenocorticotropin (ACTH) = corticotropin
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Basophil (human)
CRH (+)
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Image of cords of cells in anterior pituitary removed. Original here: Bailey's textbook of histology. 72(700)6
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Sep 11, 2013 Medical Histology slide collection, slide MHUmar Stan Erlandsen 9/B/4 Ahmad
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Basophil
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A.K. Christensen
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Nucleus
Nucleus LH granules
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Anterior pituitary, EM
Larry Kahn
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Golgi
Secretory granule
Rough ER
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Golgi Granule
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Sep 11,Marilyn 2013Farquhar in Memoirs of the Society for Endocrinology Umar Ahmad
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Hedges, 1987
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O'Riordan et al 1988, p 47
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Murakami T, 1975, Archivum Histologicum Japanicum 38:151-168
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Posterior pituitary
Hormones
Antidiuretic hormone (ADH = arginine vasopressin) Oxytocin
Neurosecretion
Hormones synthesized as part of larger proteins (neurophysins) in neuron cell bodies of hypothalamus. Transported in axons to pars nervosa (hormone cleaved from neurophysin). Hormone secreted from axon terminals into capillaries.
Pituicytes
Specialized glia of pars nervosa.
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O'Riordan et al 1988, p 47
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Posterior pituitary, LM
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Endings
Capillary
Pituicyte
Weiss Histology, ed 5
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Anterior
Posterior
Intermedia
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Humio Mizoguti, Kobe Univ Sch Med, slide 516
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ADRENAL GLAND
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US Federal Government
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Baileys Histology
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Adrenal cortex
Zona glomerulosa
Main hormone: Aldosterone (a mineralocorticoid). General function: Maintain blood electrolyte balance. Main control: Angiotensin II.
Zona fasciculata
Main hormone: Cortisol (a glucocorticoid). General function: Includes regulating glucose and fatty acid metabolism, and response to stress. Main control: Pituitary ACTH.
Zona reticularis
Hormones: Some cortisol and androgens. Function and control: Similar to zona fasciculata.
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Image of adrenal gland vasculature removed. Original here: Junqueira and Carneiro, 10th ed., 2003, page 414, fig 21-2.
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Fasciculata
Sep 11, 2013 Humio Mizoguti, Kobe Univ Sch Med, slide 548
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Zona fasciculata, EM
SER
Endothelium
Capillary lumen
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Zona reticularis, LM
Medulla
Zona fasciculata
Sep 11, 2013 Humio Mizoguti, Kobe Univ Sch Med, slide 550
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Adrenal medulla
Hormones
Epinephrine (adrenalin) and norepinephrine (noradrenalin), both catecholamines. Two cell types, one for E and one for N. General function: Acute response to stress. Main control: Preganglionic sympathetic innervation.
Embryonic source
From neural crest cells, same as postganglionic sympathetic neurons. Although adrenal medulla cells do not have dendrites or axons, they behave like postganglionic sympathetic neurons, releasing norepinephrine/epinephrine in response to preganglionic sympathetic stimulation.
Adrenal medulla, LM
Sep 11, 2013 Humio Mizoguti, Kobe Univ Sch Med, slide 565
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Norepinephrine
Epinephrine
Nucleus
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Nucleus
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THYROID GLAND
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Thyroid gland
Thyroid follicles
Thyroid hormones: thyroxine (T4), triiodothyronine (T3). Synthesis: A very large protein, thyroglobulin (660 kDa), is synthesized and then secreted into the follicle lumen. It is later taken up and broken down (with lysosomes) to yield T4 and T3. General function: To increase the body's metabolic rate. Main control: Pituitary TSH.
Thyroid follicle
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Blood vessel
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Thyroid follicles, LM
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Thyroid follicles, LM
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Colloid
Modified from Junqueira and Carneiro, 10th ed., 2003, page 426, fig. 21-19 by R. Mortensen
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Colloid
Golgi
Nucleus
Lysosome
Porter and Bonneville, 1968, Fine structure of cells and tissues, 3rd ed
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Causes of goiter
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Normal
Image of thyroid follicles removed. Original here: 0'Riordan, 2nd ed, p 160.
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Sep 11, 2013 Umar Ahmad Medical Histology atlas by Stanley L. Erlandsen and Jean E. Magney
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Thyroid gland
Parafollicular cells (= C-cells)
Hormone: Calcitonin. General function: Lowers serum calcium. Main control: Serum calcium level.
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C-cell
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Junqueira histology textbook
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PARATHYROID GLAND
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US Federal Government
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Parathyroid gland
Chief (or principal) cells
Hormone: Parathyroid hormone (PTH). Main function: Raises serum calcium, lowers serum phosphate. Main control: Serum calcium level.
Oxyphil cells
Occasional cells or small clusters. Function unknown. Name means "acid [stain] loving" (Greek).
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Blood vessel
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Fat cell
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Fat cell
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Nucleus
Mitochondrion
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Thomas Lentz atlas
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