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Metabolism in the sense of simply the body's rate of burning calories to survive.
Lipid metabolism is a lipid or fat burning process, or the process of decomposition or adjustment of fat in the body.
Metabolism of lipids or fats in the body occur in the heart/ liver. Lipid we obtain as a main energy source is of neutral lipids, ie triglycerides (esters of the glycerol with 3 fatty acids).
3. Lipid that is synthesized in the body (endogenous) from the liver to other tissues (VLDL, LDL);
4. Reverse transport of cholesterol from extrahepatic tissues to the liver to be excreted through the bile (HDL).
Cholesterol is present in the network, such as structural components of membranes. Cholesterol serves as a component of cell membranes and precursors of steroid hormones (corticosteroids, sex hormones, etc.), acids / bile salts, vitamin D.
Cholesterol contributes to the pathogenesis of atherosclerosis artery causing cerebrovascular disease, coronary and peripheral vessels.
Cholesterol in the body comes from the diet or can be synthesized from acetyl-CoA.
Cholesterol synthesis
LIPID
Fatty
GLYCEROL METABOLISM
Free fatty acids are generally in the form of fatty acids, long chain. Long-chain fatty acids will be able to enter into the mitochondria with the help of carnitine compound, with the formula (CH3) 3N +-CH2-CH (OH)-CH2COO-.
The mechanism of transport of trans fatty acids through the mitochondrial membrane carnitine transport mechanism
In the beta oxidation of fatty acids into the series with 5 cycles at each stage of the process and the process, raised two atom C with the end result in the form of acetyl CoA. Furthermore, acetyl CoA into the citric acid cycle. In the process of oxidation, fatty acid carbon is oxidized to ketones.
Description: The frequency of oxidation is ( the number of atoms C) -1 The number of acetyl CoA produced is (1/2 the number of atoms C) Oxidation of fatty acids with 16 atom C. Note that each process termination 2 C atom is oxidation and every
Activation of fatty acids, beta oxidation and the citric acid cycle
Once inside mitochondria, acyl-CoA will experience the stages of change as follows:
Acyl-CoA is converted into trans-delta2-enoil-CoA. At this stage occurs the respiratory chain by producing energy 2P (+2 C)
L (+)-3-hydroxy-acyl-CoA is converted into 3-Ketoasil-CoA. At this stage occurs the respiratory chain by producing energy 3P (+3 P) Furthermore, acetyl CoA formed containing two C atoms and acyl-CoA which has lost two atom C.
asam lemak memiliki banyak atom C, maka asil-KoA mengalami oksidasi beta kembali dan kehilangan lagi 2 atom C membentuk asetil KoA, seterusnya hingga hasil yang terakhir adalah 2 asetil-KoA
Asetil-KoA yang dihasilkan oleh oksidasi beta ini selanjutnya akan masuk siklus asam sitrat.
KETOGENESYS PROCESS
steroi d
Running Cholesterogenesys
FUCTION OF LIPID
3. Conclusion
Metabolism LIPID
Biokimia
Metabolisme Lipid
The conclusion from the above discussion are: A. Lipid metabolism is a lipid or fat burning process, or the process of decomposition or adjustment of fat in the body. Metabolism of lipids or fats in the body occur in the heart / liver. Performed by lipase found in the intestine and lymph node pancreas, the optimum pH from 7.5 to 8.
The types of lipid metabolism include: 1) Metabolism of glycerol. 2) oxidation of fatty acids (beta oxidation)
Biokimia
Metabolisme Lipid
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