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Syndrome (AIDS)
AIDS
Means Acquired Immune Deficiency
Syndrome.
It is acquired, which means it is
neither hereditary nor inborn.
It involves immune deficiency
It is a syndrome, a combination of
signs and symptoms that form a
district clinical picture of disorder
HIV
Refers to the Human
Immunodeficiency Virus which causes
AIDS.
It is retrovirus
It belongs to lentivirus,which is
sometimes called “slow virus”
The period between infection and the
appearance of AIDS can take from 7
to 12 years.
Pathophysiology
Human beings produce antibodies
against specific infections. When HIV
infection takes place,anti-HIV
antibodies are produced but they do
not appear immediately. This is called
the “window effect”
In some cases, antibodies to HIV
become detectable 4 to 6 weeks after
infection.
When HIV is in circulation, it invades
several types of cells – the lymphocytes,
macrophages, the Langerhans cells and
neurons within the CNS.
HIV attacks the body’s immune system.
The organism attaches to a protein
molecule called CD4 which is found in the
surface of T4 cells.
Once the virus enters the T4,it inserts its
genetic materials into the T4 cell’s nucleus
taking over the cell to replicate itself.
Eventually the T4 cell dies after having
been used to replicate HIV.
The virus mutates rapidly making it more
difficult for the body’s immune system to
recognize the invaders.
HIV infection progresses through several
stages.
The Clinical course of HIV infection
begins when a person becomes infected
with HIV through:
Sexual contact with infected person
Injection of infected blood or blood
products
Perinatal or vertical transmission
SIGNS AND SYMPTOMS
Minor Signs
Persistent cough for one month
Generalized pruritic dermamatitis
Recurrent herpes zoster
Oropharyngeal candidiasis
Chronic disseminated herpes simplex
Generalized lymphadenopathy
Major Signs
Loss of weight – 10 % of body weight
Chronic diarrhea for more than one
month
Prolonged fever for one month
Common Opportunistic Infections
Pneumocystis carinii pneumonia
Oral candidiasis
Toxoplasmosis of the CNS
Chronic diarrhea/wasting syndrome
Cancers
f. Kaposi's sarcoma
g. Cervical dysplasia and Cancer
h. Non-Hodgkin’s lyphoma
Mode of Transmission
Sexual intercourse
Blood transfusion and sharing of
infected syringes and needles among
intravenous drug users
Vertical or perinatal transmission
Several Ways of Receiving Infect
Blood transfusion
Sharing of unsterilized syringes and
needles used for intravenous
injections
Transmission during pregnancy
Organ donation
Accidental exposure in hospitals or
clinics
Diagnostic Examination
EIA or ELISA-enzyme link
immunosorbent assay
Particle agglutination (PA) test
Western blot analysis-confirmatory
diagnostic test
Immunoflourescent test
Radio immuno-precipitation assay
(RIPA)
Treatment Modalities
AIDS drugs are medicines usec to
treat but not to cure HIV infection.
These drugs are sometimes reffered
to as “anteroviral drugs”
Two groups of Anteroviral Drugs
1.Reverse Transcriptase Inhibitors-they inhibit
the enzyme called reverses transcriptase
which is needed to “copy” information for
the virus to replicate.
These drugs are:
Health Education
Practice Universal/standard
precaution
prevention
Four C’s in the Management of
HIV/AIDS
Compliance
Counseling/education
Contact tracing
Condoms
The End