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AP Biology
5.1 MITOSIS
4.
5. 6.
State The Necessity For The Production Of New Cells In Organisms Explain The Necessity For The Production Of New Cells Identical To Parent Cells State The Significance Of Mitosis Identify The Phases In The Cell Cycle Explain The Process Of Mitosis And Cytokines Arrange The Various Stages Of Mitosis In The Correct Sequence
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1. The necessity for the production of new cells in organisms (LO) 5 SIGNIFICANCE OF MITOSIS 1.produces new cells for growth in living
multicellular organisms 2. Repair damage tissues. eg liver cells 3. The basis of asexual reproduction in unicellular organisms such as Amoeba sp. 4. Ensure that the offspring/new cells are genetically identical to the parent. 5. replaces dead cells. Eg Skin cells
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2.The necessity for the production of new cells identical to parent cells(LO) 1. Species survival 2. preserve the diploid number of 3. 4.
chromosomes preserve the genetic information to preserve the parent characteristics
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THE CELL CYCLE The cell cycle is the period that extends
from the time a new cell is produced until the time the cell completes a cell division The cell cycle can be divided into two major phase: 1. Interphase (G1, S and G2 sub-phases) 2. mitotic cell division or M phase (mitosis and cytokinesis)
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Cell division
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G1 = 1st Gap
cell doing its everyday job cell grows
S = DNA Synthesis
copies chromosomes
G2 = 2nd Gap
prepares for division cell grows produces organelles,
proteins, membranes
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Places where the mitosis occur during the division of cell all somatic (in animal) cells which are
all body cells except gametes meristem cells ( in plant) at the end of the shoots, the end of roots and cambium.
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CHROMOSOME DUPLICATION
DNA REPLICATION
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REPLIKASI DNA
KROMOSOM MANUSIA
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THE CELL CYCLE; M phase Fasa M After the interphase stage, the dividing
cells enter the M phase. -mitosis can be further divided into four phases namely Prophase IN SEQUENCE Metaphase DALAM TURUTAN Anaphase Telophase
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Kromosom adalah tidak kelihatan tetapi muncul sebagai struktur berbentuk bebenang yang dipanggil kromatin.
Nucleus is large and prominent.
Centomere
sentromer
Spindle fibre
Gentian gelendong
Sister chromatid
sentriol
Metaphase plate
Satah khatulistiwa
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Gambarajah
Cytokinesis in Animal cell
Penerangan
In animal cell, actin filaments in the cytoplasm contracts to pull a ring of plasma membrane inwards.
Bagi sel haiwan, filament aktin dalam sitoplasma mengecut dan menarik membran plasma ke dalam.
Forming a groove cleavage furrow called a
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Gambarajah
Cytikinesis in Plant cell
Penerangan
1.Vesicle forming a cell plates
Sel tumbuhan
Plat sel bercantum membentuk dinding sel dan membrane sel yang baru.
cell plates
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Cytokinesis in Plants
Plants
vesicles move to equator line up & fuse to form 2 membranes = cell plate
derived
from Golgi
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REMEMBER!
Interphase Prophase Metaphase Anaphase Telophase
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IPMAT
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There are several factors that regulate the cell cycle and assure a cell divides correctly.
1.Before a cell divides, the DNA is checked to make sure it has replicated correctly. (If DNA does not copy itself correctly, a gene mutation AP Biology occurs.
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Neighboring cells communicate with dividing cells to regulate their growth also.
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Cancer is a disease of the cell cycle. Some of the bodys cells divide uncontrollably and tumors form.
Tumors in Liver Tumor in Colon
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While normal cells will stop dividing if there is a mutation in the DNA, cancer cells will continue to divide with mutation.
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Due to DNA mutations, cancer cells ignore the chemical signals that start and stop the cell cycle.
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Due to DNA mutations, cancer cells cannot communicate with neighboring cells. Cells continue to grow and form tumors.
Skin cancer
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Carcinogens
Ionising radiation X Rays, UV light Chemicals tar from cigarettes
Benign or malignant?
Benign tumours do not spread from their site of
origin, but can crowd out (squash) surrounding cells eg brain tumour, warts.
site and cause secondary tumours. This is called metastasis. They interfere with neighbouring cells and can block blood vessels, the gut, glands, lungs etc.
both need a huge amount of nutrients to sustain the rapid growth and division of the cells.
4. Spread of mutation
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4. Spread of mutation
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8. Angiogenesis
tumour, or perhaps by the time the tumour has broken through the basement membrane (as pictured above), angiogenesis takes place. Angiogenesis is the recruitment of blood vessels from the network of neighbouring vessels. Without blood and the nutrients it carries, a tumour would be unable to continue growing. With the new blood supply, however, the growth of the tumour accelerates; it soon contains thousand million cells and, now the size of small grape, is large enough to be detected as a lump AP a Biology
SUMMARY
Normal Cell Division Cancer Cells
1. DNA is replicated
properly. 2. Chemical signals start and stop the cell cycle. 3. Cells communicate with each other so they dont become overcrowded.
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1. Mutations occur in
the DNA when it is replicated. 2. Chemical signals that start and stop the cell cycle are ignored. 3. Cells do not communicate with each other and tumors form.
Treating Cancers
Cancer treatments include drugs that can stop cancer cells from dividing.
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Identical Twins
Sperm fertilizes egg
Fertilized egg starts to divide into a embryo, but the cells separate and each cell becomes a baby
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splits
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Cloning procedure
1. Somatic cells (from the liver cells) are removed and grown in a culture.
Sel soma (daripada sel hati) dikeluarkan dan dibesarkan dalam kultur. 2.The nucleus is sucked out, leaving the cytoplasm and organnelles without any chromosomes. Nukleus dikeluarkan, meninggalkan sitoplasma dan organel tanpa kromosom. 3.An electrical pulse stimulates the fusion between the somatic cell and the egg cell without nucleus. Isyarat elektrik menggaktifkan pergabungan antara sel soma dengan sel telur tanpa nukleus. 4.The cell divides repeatedly, forming an embryo. Sel membahagi berulang-ulang, membentuk embrio. 5.The embryo is then implanted into surrogate mother. Embrio kemudiannya dilekatkan dalam ibu tumpang. 6.Then, Dolly the cloned sheep of the somatic cell donor is born AP BiologyDolly kambing biri-biri daripada sel soma penderma dilahirkan. Kemudian,
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Explanation
1. Wash the tomato plant tissue with hypochloric solution. Basuh tisu pokok tomato dengan larutan hipoklorik. 2. Tomato tissue are cultured in a sterile medium rich in nutrients Tisu adalah dikultur dalam medium yang kaya dengan nutrien 3. After the callus (undifferentiated mass of tissue) is formed, transfer the tissue culture to a new sterile medium rich in nutrients which contain growth hormone. Selepas kalus terbentuk, pindahkan kultur tisu ke dalam tempat medium baru yang kaya dengan nutrient yang mengandungi hormon pembesaran. 4. After the shoots is formed, transfer them into the plant pod Selepas pucuk terbentuk, pindahkan ke pasu.
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Advantages/ kelebihan
Disadvantages/kekurangan
Ensure the continuity of hereditary traits from the parent to the clones. Increase the rate of production and the quality of the products Good qualities of the plants and animals can be selected and maintained in the clones. Many clones are produced in a short time. Can be carried out any time of the year.
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The resistance of the clones towards diseases and pests is the same. If a clone is infected with a disease or attacked by pests then all the clones will also affected and die.
What inference can be made from the above diagram? I. The lamb is produced by asexual reproduction II The nucleus of the egg cell from sheep Q is removed III The characteristics of the lamb are the same as in sheeps P and Q IV The early embryo cells contain similar chromosomes as sheep P A I, II and III only B I, II and IV only C II, III and IV only D I, II, III, and IV Answer/ Jawapan: B
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