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SVT Algorithm
The difference in therapy between Stable and Unstable patients: Stable Patients pharmacology first. Unstable Patients electricity first. The form of electricity is Cardioversion This will be covered in detail during the lab sessions.
Treatment Modalities
Adenosine Calcium Channel Blockers Beta Blockers Synchronized Cardioversion
Adenosine
Generic Name: Adenosine Trade Name: Adenocard
Adenosine Indications
First line medication for most forms of narrow-QRS supraventricular tachycardia (SVT)
Adenosine Precautions
Facial flushing Coughing/dyspnea, bronchospasm Nausea Headache Hypotension Chest pressure Lightheadedness Paresthesias Dysrhythmias at time of rhythm conversion Use with caution in patients with emphysema, bronchitis Avoid in patients with asthma Discontinue in any patient who develops severe respiratory difficulty
Adenosine Contraindications
Poison/drug-induced tachycardia Asthma 2nd or 3rd degree AV Block Sick sinus syndrome (except in clients with a functioning artificial pacemaker) Atrial flutter/atrial fibrillation Ventricular tachycardia
SECONDS!!!!!
Atrial flutter/fibrillation: for rate control Patients with normal LV function (diltiazem, verapamil Class I) Patients with impaired LV function (diltiazem Class IIb) Pre-excited atrial fibrillation (WPW) Patients with normal LV function (diltiazem, verapamil Class III)
Diltiazem depresses myocardial contractility to a lesser degree than verapamil and causes less hypotension. During administration, monitor closely for hypotension and AV block.
Beta Blockers
Generic/ Trade Names: Atenolol (Tenormin) Esmolol (Brevibloc) Labetalol (Normodyne, Trandate) Metoprolol (Lopressor) Propranolol (Inderal) Classification: Beta-blockers
Beta Blockers
1) 2) 3) 4) 5) How Supplied: Atenolol injection: 5mg/10m Esmolol injection: 100 mg/10 ml single-dose vial Labetalol injection: 5 mg/ml in 20 ml ampule; 20, 40, 60 ml multi-dose vials Metoprolol injection: 1 mg/ml in 5 ml ampule Propranolol injection: 20 mg/5 ml unit-dose containers; 40 mg 5 ml unit dose containers
Non-ST segment elevation MI or unstable angina (Class I) Adjunctive agent with fibrinolytic therapy To reduce incidence of VF in post-MI patients who did not receive fibrinolytics (atenolol, metoprolol, propranolol)
Beta-Blockers Precautions
Atenolol Use with caution in patients with impaired renal function
Esmolol In clinical trials 20 to 50% of patients experienced hypotension, SBP <90 mmHg and/or DBP < 50 mmHg. Monitor patients closely, especially if pretreatment BP low. Decrease of dose or termination of infusion reverses hypotension, usually within 30 minutes. Infiltration and extravasation may result in skin sloughing and necrosis. Administer with caution in patients with impaired renal function Fatal cardiac arrests have occurred in patients receiving esmolol and verapamil
Cardiology Diazepam
Generic Name: Diazepam Trade Name: Valium
Classification: Anticonvulsant and sedative. Benzodiazepine. How Supplied: Ampules and prefilled syringes containing 10 mg in 2 ml of solvent.
Suppresses the spread of seizure activity through the motor cortex of the brain. It does not appear to abolish the abnormal discharge focus. It induces amnesia
Diazepam Indications
Major motor seizures. Status epilepticus Premedication before cardioversion Skeletal muscle relaxant Acute anxiety states
Diazepam Contraindications
Should not be administered to any patient with a history of hypersensitivity to the drug.
Diazepam Precautions
Because of its relatively short-action, seizure activity may recur. Flumazenil (Romazicon), a benzodiazepine antagonist, should be available to use as antidote if required. Injectable diazepam can cause local venous irritation. To minimize irritation, it should only be injected into relatively large veins and should not be given faster than 1 ml/min.
Diazepam Dosage
In the management of seizures, the usual dose is 5 to 10 mg IV. In acute anxiety reactions, the standard dosage is 2 to 5 mg administered intramuscularly. To induce amnesia prior to cardioversion, a dosage of 5 to 15 mg is given IV.
Midazolam
Generic Name: Midazolam
Midazolam Indications
Premedication before cardioversion and other painful procedures.
Midazolam Contraindications
Should not be administered to any patient with a history of hypersensitivity to the drug. It should not be used in patients who have narrow-angle glaucoma. Should not be administered to patients in shock, with depressed vital signs, or who are in alcoholic coma.
Midazolam Precautions
Intubation equipment must be available prior to the administration of midazolam. Vital signs must be continuously monitored during and after drug administration. Has more potential than the other benzodiazepines to cause respiratory depression and respiratory arrest. Flumazenil (Romazicon), should be available to use as antidote if required
Midazolam Dosage
For sedation typically .1 to 2. mg are administered by slow IV injection. Best to dilute midazolam with NSS or D5W.
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