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Kidneys Excrete Excess Water by Forming Dilute Urine ADH (Vasopressin) Controls Urine Concentration Renal Mechanisms for Excreting Dilute Urine
Fig. 28.2 Formation of dilute urine when ADH levels are very low
Water Deficitkidney excretes solutes but reabsorbs water therefore decreasing the volume formed
Urine Specific Gravity
Fig. 28.3 Relationship between specific gravity and osmolarity of the urine
Kidneys Conserve Water by Excreting Concentrated Urine Countercurrent Mechanism Produces a Hyperosmotic Renal Medullary Interstitium a. Buildup of solute concentration in the medulla 1. Active transport of Na and cotransport of K, Cl, and other ions from the loop of Henle 2. Active transport of ions from the collecting ducts 3. Facilitated diffusion of urea from collecting ducts 4. Diffusion of water from the tubules
Water Permeability
++ ++ 0
NaCl Permeability
+ + +
Urea Permeability
+ + +
++ 0 0
Thick Ascending
Dist. Tubule Cortical Coll. Tubule Inner med. Coll. Duct
++
+ + +
0
+ADH +ADH +ADH
0
0 0 0
0
0 0 ++ADH
Conserving Water (cont.) Steps Involved in Causing Hyperosmotic Renal Medullary Interstitium
Fig. 28.4 Countercurrent multiplier system in the loop of Henle for producing a hyperosmotic renal medulla (values are in milliosmoles per liter
Conserving Water (cont.) Role of Distal Tubule and Collecting Ducts in Excreting Concentrated Urine
Fig. 28.5 Formation of a concentrated urine when ADH levels are high.
Conserving Water (cont.) Urea Contributes to Hyperosmotic Renal Medullary Interstitium and Formation of Concentrated Urine Recirculation of Urea from Collecting Duct to Loop of Henle Contributes to Hyperosmotic Renal Medulla a. In general the rate of urea excretion is determined by 1. The concentration of urea in the plasma 2. The glomerular filtration rate
Fig. 28.6 Recirculation of urea absorbed from the medullary collecting duct into the interstitial fluid
Countercurrent Exchange in the Vasa Recta Preserves Hyperosmolarity of the Renal Medulla
a. Two features that contribute to the preservation of high solute concentrations 1. The medullary blood flow is low 2. The vasa recta serve as countercurrent exchangers Increased Medullary Blood Flow reduces Urine Concentrating Ability
Conserving Water (cont.) Summary of Urine concentrating Mechanism and Changes in Osmolarity in Different Segments of the Tubules
Fig. 28.8
a. Na ions in the ECF and associated anions are the principal determinants of fluid movement across the cell membrane
Fig. 28.9 Osmoreceptor-ADH feedback mechanism for regulating ECF osmolarity in response to a water deficit
Osmoreceptor-ADH Feedback System ADH Synthesis in the Hypothalamus and Release from the Posterior Pituitary
Fig. 28.10
Osmoreceptor-ADH Feedback System Stimulation of ADH Release a. Arterial baroreceptor reflexes b. Cardiopulmonary reflexes c. Decreased arterial pressure d. Decreased blood volume
Osmoreceptor-ADH Feedback System Either a decrease in effective blood volume or an increase in ECF osmolarity stimulates ADH secretion
Fig. 28.11 The effect of increased plasma osmolarity or decreased blood volume on the level of plasma ADH
Hypoxia
Drugs: Morphine Nicotine Cyclophosphamide
Hypoxia
Drugs: Alcohol Clonidine (antihypertensive) Haloperidol (dopamine blocker)
Thirst (cont.)