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A glance at Mushroom Poisoning
• Magnitude of problem
1. Cyclopeptide-containing Mushrooms
2. Monomethylhydrazine-containing Mushrooms
3.Muscarine-containing Mushrooms
4. Coprine-containing Mushrooms
5. Ibotenic Acid and Muscimol- containing Mushrooms
6. Psilocybin-containing Mushrooms
7. Gastrointestinal Toxins
8. Orelline & Orellanine- containing Mushrooms
Gr oup I - Cyclopeptide-containing Mushroom
Omphalotus olearius
Musca rin e C lini cal
Eff ects:
• Onset within 30 to 120 minutes
• Clinical Feature: like OP Poisoning
• Recovery in 6 to 24 hours
Musca rin e Treatm ent :
• Standard decontamination methods
• In symptomatic patients
– Atropine 1mg to 2mg for adults
– and children
• 0 to 2 years .2 mg
• 3 to 4 years .3 mg
• 5 to 10 years .4mg
Group IV – C oprine-cont ai nin g
Mus hrooms :
• Coprinus atramentarius “Inky caps”
• Toxin is coprine,
• The metabolite of which inhibits aldehyde
dehydrogenase
• Ingestion is asymptomatic unless ethanol is
consumed in the following 2 hours to 5 days
– Disulfiram like effect
Coprinus atramentarius
Copr ine Treatment :
• Decontamination
• Symptomatic treatment
– B-blockers or sedatives for anxiety and
tachycardia
• Fluids for hypotension
Group V -
Musci mol /Iboteni c Aci d-
contai ni ng Mushrooms :
• Amanita Muscaria, Amanita Pantherina,
Amanita Gemmata
• Toxin is Ibotenic acid which is metabolized to
Muscimol
• Muscimol is a false neurotransmitter which
stimulates GABA receptors and usually results
in anticholinergic symptoms
Amanita gemmata
Cl ini cal Ef fects :
General Morphology :