INFEKSI VIRUS PADA REPRODUCTIVE SYSTEM

Dr.Gerben F. Hutabarat DTM&H, MSc, SpMK

I.

DNA VIRUS 1. HERPES SIMPLEX VIRUS (HSV) 2. CYTOMEGALO VIRUS (CMV) 3. PAPILOMA VIRUS (HPV) 4. PARVO VIRUS (B19 virus) (Big19 V) 5. Hepatitis B. Virus (HBV)

II. RNA Virus 1. RUBI VIRUS ( RUBELLA VIRUS) 2. HUMAN IMMUNO DEFICIENCY V. (HIV) 3. MEASLES VIRUS. 4. MUMPS VIRUS.

Virus

Penyakit

Sifat Virus

Cara penularan Sexual Intercourse

Gejala

Diagnosa Lab -Isolasi -Vesicle fluid -Skin swab Inoculate -Tissue culture (BHK21) HELC -Serolgy

Preventian

Herpes Simplex Virus2 (HSV)

Gemital Herpes.

DNA double stranded 100m

- Vesicular

eruption

Neonatal Herpes

- Jaundice

Hepato splenomegal i - Therombo cytopenia - Vesicular skin

-

Virus

Penyakit

Sifat Virus

Cara penularan

Gejala

Diagnosa Lab

Preventian

Papiloma Virus (Human Papiloma Virus = HPV)

-Genital wartz (condyloma acuminata)

-DNA - Double stranded circular DNA - 50 nm

Sexual intercourse

- Marked froliferation of epithelial cell (Condyloma acuminata)

- Kilocytes in the lesion - Serology

No Vaccine

Virus

Penyakit

Sifat Virus

Cara penularan
Sexual intercourse Transplacent ally transmission. Or during delivery.

Gejala

Diagnosa Lab
- Ibu

Preventian

Hepatitis B.V. (HBV)

Hepatitis B. (acut Hepatitis B). Incubation Period : 10 12 weeks Chronic Carriers Hepato cellular carcinoma

DNA 22 nm 42 nm as Dane particles

-Jaundice

Serology HBs Ag dgn -RIA -EIA -RPA -CIE

= Vaccin Recombivax = Hyper immune globulin : - Hepatitis B Immune globulin (HBIG)

Virus

Penyakit

Sifat Virus

Cara penularan
Respiratory droplot - Transplacantal ly
-

Gejala

Diagnosa Lab
- Serology

Preventian

Rubella Virus (Rubi Virus)

Rubella (German measles) in pregnancy. Incubation periode 14 21 days

RNA 50 75 m

-Congenital

defect (Triad : cataraet, nerve defnes, cordiac abnormality) The Rubella Syndrome

HI testi Ig : rising teter - Ig M (CFT, RIH)

-Vaccein 1. dose s. e (Live attenunated Virus Vaccin.

HIV

AIDS Rna

-Sexual-contact -Transferof infected blood -Transplacen tally

- Serology

Elisa

: Ab - Western blot

Novaccine is available

Virus

Penyakit

Sifat Virus

Cara penularan

Gejala

Diagnosa Lab

Preventian

Measles

Measles = Rubeola = Morbili

- RNA - 120-250 - 0ne

nm

Inkalation Respiratory secretion

Fatal death

Isolation in cell culture Serology rising titugreater than 4 fold

Life long Immunity

Incubation Periode : 10 14 days

serological type

Gejal pd ibu - Fever - Conjunetivitis - Running nose - coughing

-

Measles Vaccine One dose s.e Life attenuated vaccine

- Kopling spots in buccal

Virus

Penyakit

Sifat Virus

Cara penularan
- Droplet infection

Gejala

Diagnosa Lab
Serology CFT use : SAg (Saluble Ag) V Ag (Viral Ag) Culture Saliva, spinal fluid, urine.

Preventian

Mump V.

Mumps Parotitis epidemica Life long Immunity Maternal antibody passes the placenta immunity frist 6 month of life. Incubation period 18 21 days

- RNA

- 110

170 nm - Envelope particles

-Fever malaise anomxia. - Tender swalling parotid gland

Mumps Vaccine

Life attenuated vaccine

Virus

Penyakit

Sifat Virus

Cara penularan
-Sexual intercouse, blood transfusion Transplacentall y in utero

Gejala

Diagnosa Lab
-Isolasi

Preventian

Cytomegalo Virus (CMV)

Cytomegalic Inclusion Disease (CID)

-DNA

-Fetus -mental retardation -Jaundice -Hepsplermegali -Blood discrasis (thrombocyto penia) Haemolytie anemia -Microcephali -Motor diseases

urine -throat swab -Inoculasi HELC CPE Swallen cell -Serologi CFT, IF

Virus

Penyakit

Sifat Virus

Cara penularan
-Respiratory route -Blood transfusions
-Transplacental transmission (Infection frist trisemester)

Gejala

Diagnosa Lab
-Detecting

Preventian

Parvovirus B19

Slappetdtchee ks syndrome, -Fifth disease -Aplastic anemia -Fetal infections

-DNA -Single stranded genome

-Fetal

death

IgM -Isolation from throat swabs -PCR Dna for blood amniotic fluid