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Asphyxia neonatorum is respiratory failure in the newborn, a condition caused by the inadequate intake of oxygen before, during, or just after birth.
Asphyxia neonatorum, also called birth or newborn asphyxia, is defined as a failure to start regular respiration within a minute of birth.
syndrom of early (in birth, during the first minutes of life) depression of the main vital functions, including bradycardia, reduced muscle tone, hypoventilation, hypotension, but usually without hypoxemia and hypercarbia. As a rule in the newborn are present one or two signs of these vital functions depression and Apgar score of 4-6 at the first minute.
8. Severe somatic diseases in pregnant women. 9. Smoking or drug addiction in pregnant women. 10. Intrauterine growth restriction or another diseases revealed in fetus in ultrasound examination.
7. Birth trauma. 8. Congenital malformations of fetus. 9. Acute labor hypoxia in mother (shock, amniotic fluid embolism, poisonings, decompensated diseases). 10. Maternal anesthesia (both the intravenous drugs and the anesthetic gases cross the placenta and may sedate the fetus).
There are 5 basic pathogenetic mechanisms which lead to the development of the acute asphyxia neonatorum:
1) Blood flow interraption through the umbilical cord (tight umbilical cord entanglement around of a neck - loop of cord) 2) Disturbances of gaseous exchange through the placenta (placental abruption, placental presentation)
3) Unequal blood supply of the maternal part of placenta (very intensive labour activity, hypertension of any etiology in mother) 4) Worsening of blood oxygenation in mother (anemia, cardio-vascular diseases, respiratory insufficiency) 5) Failure of respiratory efforts of the newborn (iatrogenic drug induced, caused by congenital malformations).
SIGN
0 Heart rate Absent
SCORE
1 Less than 100/min 2 Over 100/min
Respiratory effort
Absent
Muscle tone Atony Reflex irritability Color No response Universal cyanosis or pallor
If Apgar score is 0-3 at the first minute neonatal mortality is 5,6 %. Nelson and Ellenberg examined Apgar scores in 49 000 infants. Of infants with an Apgar score 0 - 3 at 20 minutes, 59% of survivors died before 1 year, and 57% of the survivors had cerebral palsy. If Apgar score is 0-3 at the first minute and becomes 4 and more in the 5-th minute possibility of cerebral palsy is 1 %.
Per the guidelines of the American Academy of Pediatrics (AAP) and the American College of Obstetrics and Gynecology (ACOG), all of the following must be present for the designation of asphyxia (1992):
Profound metabolic or mixed acidemia (pH <7.00) in an umbilical artery blood sample, if obtained Persistence of an Apgar score of 0-3 for longer than 5 minutes Neonatal neurologic sequelae (eg, seizures, coma, hypotonia) Multiple organ involvement (eg, of the kidney, lungs, liver, heart, intestines)
Step 2.
-Provide warmth -Position; clear airway (as necessary) -Dry, stimulate, reposition -Give O2 (as necessary)
Grade 3: severe encephalopathy with a stuporous, flaccid infant, and absent reflexes. The infant may have seizures and has an abnormal EEG with decreased background activity and/or voltage suppression.