Lymphoreticuler Pathology

Lymphoreticuler Phatology
Histiositosis Inflammation Primary tumor Secondary tumor

= Langerhans cell histiocytosis

Letterer Siwe disease (M9754/3) Hand Schuller-Christian disease (M9753/1) Eosinophilic granuloma (M9752/1) - Gaucher disease - Niemann Pick disease - Glicogenosis disease - Sinus histiositosis
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Histiositosis

Hans Schuller Christian

Hans Schuller Christian

Gaucher

Gaucher

Sinus cattarh

kgb skematis

Kgb organ

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Inflammation
Acute lymphadenitis Chronic lymphadenitis Dermatophatic lymphadenopathy Toxoplasmosis Kikuchi disease Kimura disease

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Chronic lymphadenitis

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Chronic lymphadenitis

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Chronic lymphadenitis

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Dermatophatic lymphadenopathy

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Dermatophatic lymphadenopathy

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Lymphadenitis tbc

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Lymphadenitis Toxo

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Lymphadenitis Toxo

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Kikuchi

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Kikuchi

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Kikuchi

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Tumor
Leukemia B cell lymphoma T cell lymphoma Hodgkin lymphoma

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Leukemia
= malignant tumor of the lymphoid tissue (lymphoid cells), primary in bone marrow 1. Acute leukemia (lymphoblastic) 2. Chronic leukemia (lymphocytic) 3. Other leukemia
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Maturation of B lymphocytes

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B-cell malignant lymphoma

1. Chronic lymphocytic leukemia/small lymphocytic lymphoma 2. B-cell prolymphocytic leukemia 3. Splenic B-cell marginal zone lymphoma 4. Hairy cell leukemia 5. Splenic B-cell lymphoma, unclassifiable 6. Lymphoplasmacytic lymphoma 7. Heavy chain diseases 8. Plasma cell neoplasms 9. Extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue (MALT lymphoma)
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B-cell malignant lymphoma

10. Nodal marginal zone lymphoma 11. Follicular lymphoma 12. Primary cutaneous follicle centre lymphoma 13. Mantle cell lymphoma 14. Diffuse large B-cell lymphoma (DLBCL) 15. DLBCL associated with chronic inflammation 16. Lymphomatoid granulomatosis 17. Primary mediastinal large B-cell lymphoma

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B-cell malignant lymphoma

18. Intravascular large B-cell lymphoma 19. ALK positive large B-cell lymphoma 20. Plasmablastic lymphoma 21. LBCL arising in HHV8-associated multicentric Castleman disease 22. Primary effusion lymphoma 23. Burkitt lymphoma 24. B-cell lymphoma, unclassifiable 25. Hodgkin lymphoma

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The frequent B cell lymphoma

Chronic lymphocytic leukemia/small lymphocytic lymphoma Plasma cell neoplasma MALT lymphoma Follicular lymphoma Diffuse large B cell lymphoma (DLBCL) Burkitt lymphoma Mantle cell lymphoma Hodgkin lymphoma
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Malignant lymphoma and type of cells

CLL / SLL Plasma cell neoplasma MALT lymphoma Follicular lymphoma DLBCL Burkitt Mantle cell lymphoma Hodgkin lymphoma Naive B cell Long lived plasma cell Memory B cells marginal zone Centroblast dan centrosit Centroblast, immunoblast, anaplastic cells Small centroblast (B blast) Mantle cells Sel Hodgkin atau sel datia Reed Sternberg
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B cell lymphoma
Working formulation, not recommended any more Each type of ML should be separated in patient management eg: Mantle cell lymphoma Lymphocytic lymphoma
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SLL

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SLL

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Lymphoblastic lymphoma

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Lymphoblastic lymphoma

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Mantle cell lymphoma

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Mantle cell lymphoma

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Burkitt lymphoma

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Burkitt lymphoma

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Follicular lymphoma

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Follicular lymphoma

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Follicular lymphoma

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Large cell lymphoma

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Large cell lymphoma

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Plasmacytoid lymphoma

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Plasmacytoid lymphoma

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T cell maturation

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NK cell
Extranodal NK/TCL nasal type Chronic LPD NK cell Aggressive NK cell leukemia

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 T cell
Hepatosplenic T cell lymphoma Enteropathy associated T cell lymphoma Primary cut CD 30 + T cell LPD Primary cut GD T cell lymphoma

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 T cell
Subcutaneous Pan. like T cell lymphoma T cell Prolymphocytic leukemia

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CD 8+ T cell
T cell LGLL ALCL ALK + ALCL ALK EBV + T cell LPD childhood

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CD 4+ T cell
Mycosis fungoides Sezary syndrome AITL Adult T cell lymphoma

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Extranodal NK / T cell lymphoma nasal type

Vascular destruction Vasculitis Angiocentric Necrosis Inflammation

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Mycosis fungoides
Epidermotropism Cerebriform nucleus Pautrier abscess

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Angio immunoblastic T cell lymphoma

High endothelial venules proliferation Tumours cell in para cortical region or around follicle or venous vessel

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Extranodal NK / TCL nasal type

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Extranodal NK / TCL nasal type

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AITL

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AITL

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ALCL

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ALCL

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Hodgkin lymphoma
Nodular lymphocyte predominant HL Classical lymphocyte rich HL Classical mixed cellularity HL Classical lymphocyte depleted HL Classical nodular sclerosis HL

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Hodgkin lymphoma
Hodgkin cell :
Reed-Sternberg cell Mumified cell Popcorn cell Lacunar cell

CD 15 , CD 30

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a. Reed Sternberg cell classical b. & c. Mononuclear Reed Sternberg cell

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d. Pleomorphic Reed Sternberg cell e. Lacunar Reed Sternberg cell

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h. Popcorn cell

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Hodgkin nodular sclerosis

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Hodgkin nodular sclerosis

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Hodgkin mixed

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Hodgkin mixed

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Hodgkin mixed

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Hodgkin mixed

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