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B.GANGADHAR
PULMONARY EMBOLISM
• Advancing age
• Arterial disease including carotid and coronary disease
• Obesity
• Cigarette smoking
• Chronic obstructive pulmonary disease
• Personal or family history of venous thromboembolism
• Recent surgery, trauma, or immobility including stroke
• Acute infection
• Long-haul air travel
• Cancer Pregnancy, oral contraceptive pills, or hormone
replacement therapy
• Pacemaker, implantable cardiac defibrillator leads, or
indwelling central venous catheters
•
Major Thrombophilias Associated with VTE
Embolization :
• Isolated calf vein thrombi pose a much lower risk of PE, but
they are the most common source of paradoxical
embolism.
Score Points
• DVT symptoms or signs 3
• An alternative diagnosis is less likely than PE 3
• HR > 100/min
1.5
• Immobilization or surgery within 4 wk 1.5
• Prior DVT or PE 1.5
• Hemoptysis 1
• Cancer treated within 6 mo or metastatic 1
DIFFERENTIAL DIAGNOSIS.
Myocardial infarction
Pericarditis
Heart failure
Pneumonia
Asthma
Chronic obstructive pulmonary disease
Pneumothorax
Pleurodynia
Pleuritis from connective tissue disease
Thoracic herpes zoster (“shingles”)
Rib fracture
Musculoskeletal pain
Primary or metastatic intra thoracic cancer
Infra diaphragmatic processes (e.g., acute cholecystitis,
splenic infarction)
Hyperventilation syndrome
Clinical Syndromes of Pulmonary
Embolism
• Classification of Acute Pulmonary Embolism :
Classification Presentation
Therapy
Massive PE Systolic BP ≤ 90 mm Hg
Thrombolysis
or poor tissue perfusion or
embolectomy
or multisystem organ failure or
IVC filter
plus
plus
rt or ltPA thrombus
anticoagulation
or “high clot burden”
SubmassivePE Hemodynamically stablebut
Addition of thrombolysis,
mod. or sev.RVdysfunction
Clinical Syndromes of Pulmonary Embolism
• PULMONARY INFARCTION.
Caused by a tiny peripheral pulmonary embolism
Tissue infarction usually occurs 3 to 7 days after
embolism.
Pleuritic chest pain, often not responsive to
narcotics
Low-grade fever
Pleural rub
Occasional scant hemoptysis
Leukocytosis
• PARADOXICAL EMBOLISM.
small DVT that embolizes to the arterial system,
usually through a
- Incomplete
orcompleteRBBB
- Right axis deviation
-T wave inversions in
leads III and aVF or in
leads V1-V4
CHEST RADIOGRAPHY :
-A normal or near-normal CXR in a dyspneic patient
often occurs in PE.
-Well-established abnormalities include
(Hampton's hump), or
Pulmonary Angiography :
-Chest CT with contrast has virtually replaced invasive
pulmonary angiography as a diagnostic test.
• Contrast Phlebography
•
Integrated diagnostic approach
MANAGEMENT
MANAGEMENT
Risk Stratification
Predictors of Increased Mortality
• Clinical
Systolic blood pressure less than or equal to 100 mm Hg
Age older than 70 years
Heart rate higher than 100 beats/min
Congestive heart failure ,Chronic lung disease ,Cancer
Variable
Action
4 U/kg/hr
aPTT 35 - 45 seconds (1.2 -1.5 c) 40 U/kg bolus, then
by 2 U/kg/hr
• Dosing
- In an average-sized adult, warfarin is usually initiated in
a dose of 5 mg.
• Clinical Setting
Recommendation
1ST provoked PE/proximal leg DVT 6
mo
Third VTE
Indefinite duration
Inferior Vena Caval Filters
• Thrombolysis usually
(1) dissolves much of the obstructing pulmonary arterial
thrombus
(2) prevents the continued release of serotonin and other
neurohumoral
factors that exacerbate pulmonary hypertension and
(3) dissolves much of the source of the thrombus in the
pelvic or
deep leg veins, thereby decreasing the likelihood of
recurrent PE.
• Pulmonary Embolectomy