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  • Osteoporosis: Causes, Diagnosis, Prevention and Treatment

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    wsetyowulan
    35 vizualizări12 pagini
    Defining Osteoporosis Material and Structural Basis of skeletal fragility. Bone strength is sufficiently weak that fractures occur with minimal trauma Type I Type II 4 / 9 / 2014 a loss of trabecular bone after menopause Lack of endogenous estrogen. Calcium 1500 mg daily supplement Hormon therapy Vitamin D 4 /9 / 2014 norethindrone 5 mg daily.

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    Defining Osteoporosis Material and Structural Basis of skeletal fragility. Bone strength is sufficiently weak that fractures occur with minimal trauma Type I Type II 4 / 9 / 2014 a loss of trabecular bone after menopause Lack of endogenous estrogen. Calcium 1500 mg daily supplement Hormon therapy Vitamin D 4 /9 / 2014 norethindrone 5 mg daily.

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    © All Rights Reserved
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    35 vizualizări12 pagini

    Osteoporosis: Causes, Diagnosis, Prevention and Treatment

    Încărcat de

    wsetyowulan
    Defining Osteoporosis Material and Structural Basis of skeletal fragility. Bone strength is sufficiently weak that fractures occur with minimal trauma Type I Type II 4 / 9 / 2014 a loss of trabecular bone after menopause Lack of endogenous estrogen. Calcium 1500 mg daily supplement Hormon therapy Vitamin D 4 /9 / 2014 norethindrone 5 mg daily.

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    © All Rights Reserved
    Descărcați ca PPTX, PDF, TXT sau citiți online pe Scribd
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    din 12

    OSTEOPOROSIS

    Winda Setyowulan Trisakti University Bekasi City General Hospital 2014

    TOPICS
    Defining Osteoporosis Material and Structural Basis of Skeletal Fragility Skeletal Heterogeneity The Purposes of Bone Remodeling Definition of Osteoporosis Diagnosis Pathogenesis Prevention Treatment
    windasetyo@hotmail.com 2

    4/9/2014

    Defining Osteoporosis
    Osetoporosis: a condition of generalized skeletal fragility in which bone strength is sufficiently weak that fractures occur with minimal trauma

    Riggs

    Type I Type II
    4/9/2014

    A loss of trabecular bone after menopause Lack of endogenous estrogen

    A loss of cortical and trabecular bone in men and women due to age-related Long-term remodeling inefficiency,
    3

    windasetyo@hotmail.com

    Material and Structural Basis of Skeletal Fragility


    WHOLE BONE STRENGTH

    BONE SIZE mass

    BONE MORPHOLOGY shape (distribution of bone mass) microarchitecture

    PROPERTIES OF BONE MATERIAL density matrix collagen traits microdamage

    BONE REMODELING Balance of formation / resorption


    4/9/2014 windasetyo@hotmail.com 4

    Skeletal Heterogeneity
    Feature Main bone tissue Main soft tissue Main joint type Cortices Marrow Turnover Central Cancellous Viscera Various Thin Hematopoietic High Peripheral Cortical Muscle Synovial Thick Fatty Low

    Feature Bone type Location

    Red Marow Cancellous Viscera

    Yellow Marrow Cortical Muscle

    Main functions
    4/9/2014

    Various
    windasetyo@hotmail.com

    Synovial
    5

    The Purposes of Bone Remodeling


    Maintain its ability to carry out its function
    mechanical

    calcium homeostasis

    hematopoiesis

    4/9/2014

    windasetyo@hotmail.com

    Definition of Osteoporosis
    Consensus Development Conference, 1991

    a disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk

    4/9/2014

    windasetyo@hotmail.com

    Diagnosis
    Calculate the bone mineral density (BMD)!

    Useful in diagnosis, prognosis, and selection cases for treatment

    4/9/2014

    windasetyo@hotmail.com

    Pathogenesis

    4/9/2014

    windasetyo@hotmail.com

    Prevention
    Calcium 1500 mg daily supplement
    Hormon therapy Vitamin D
    4/9/2014

    Norethindrone 5 mg daily With calcium


    windasetyo@hotmail.com 10

    Treatment
    If the fasting urine calcium and bone markers are high but the urine sodium is normal, treatment can take any form that inhibits bone resorption such as calcium and/or estrogen or norenthindrone
    If the urine Na/Cr is over 15, then salt intake is high, and simple salt restriction may be sufficient to bring down bone turnover

    If radiocalcium absorption is low, it usually responds to calcitriol 0.25 mg daily unless due to an intrinsic bowel disorder such as celiac disease. It is perfectly safe to give 500-1000 mg of calcium as well and little point in giving calcitriol without calcium
    Low calcium absorption in postmenopausal women will also generally respond to estrogen or norethindrone
    4/9/2014 windasetyo@hotmail.com 11

    THANK YOU

    4/9/2014

    windasetyo@hotmail.com

    12

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