RAVAGNANI, Jr. H.A., BOTT, R.F., SOUZA, C.R.F., AND OLIVEIRA, W.P.

Department ! P"arma#e$t%#a& S#%en#e', La(ratr) ! P"arma#e$t%#a& Pr#e''e' * FCFRP+USP, A,. - Ca!., '+n., CEP /01012341, R%(e%r5 Pret 6SP7, Bra8%&
e2ma%&9 :p&%,;!#!rp.$'p.(r

ABSTRACT ABSTRACT
INTRODUCTION INTRODUCTION
<ATERIAL AND <ETHODS <ATERIAL AND <ETHODS
CONCLUSION CONCLUSION
AC=NOWLEDGE<ENTS AC=NOWLEDGE<ENTS
RESULTS AND DISCUSSION RESULTS AND DISCUSSION
Currently, considerable efforts have been directed to the development of processes for
production of dry extracts of medicinal plants. The advantages attributed to the dry extracts over
the conventional fluid form include the higher stability and concentration of the active substances
and facility of standardization and of quality control. The aim of this work is to present a process
development study for the production of dried extracts of Passiflora alata ryander !passion
flower", a plant commonly used in the #razilian folk medicine. The drying tests were carried out in
two distinct drying processes$ the conventional spouted bed and the spray drying. The ob%ective
was the identification of the most viable technology to perform this operation. The variation of
residual moisture content of the product, the particle size distribution, the flavonoid degradation
and the morphology of the dried particle were measured as a function of the inlet air temperature
and feed flow&rate of hydroalcoholic extracts. #oth drying processes produces powder extracts with
good stability and pharmacotechnical properties. The results showed that the spouted bed drying
is a viable technology for the production of dried extracts of medicinal #razilian plants.
Pa''%n !&:er' 'pe#%e', #a&&e- >mara#$?@A %n Bra8%&, are nat%,e ! t"e trp%#a& an-
'$(trp%#a& 8ne' !rm S$t" Amer%#a t Nrt" Amer%#a. T"ere are mre t"an B11 'pe#%e'
! Pa''%!&ra, (e%nC t"e Passiflora edulis t"e m't #mmn %n Bra8%& 6BALEE, /3307. Sme
'pe#%e' ! Pa''%n F&:er' are :%-e&) emp&)e- () "er(a&%'t' an- nat$ra& "ea&t"
pra#t%t%ner' a' 'e-at%,e, ")pnt%#, a' tranD$%&%8er, ant%2%n!&ammatr), %n t"e treatment !
-%'r-er' ! t"e 'E%n, %n t"e re-$#t%n ! t"e ")pera#t%,%t) %n #"%&-ren, %n %nterm%ttent !e,er',
a' ant%'pa'm-%#, pa%n re&%e,er an- 'e,era& t"er $'e' 6DU=E, /3FG7. In <nCrap"' !
A$'tr%#", Fren#", S:%t8er&an- an- Br%t%'" P"arma#pe%a' t"e Passiflora incarnata L. %' #%te-
'pe#%e ($t, %n Bra8%&, t"e Passiflora alata Dr)an-er %' t"e !!%#%a& 'pe#%e. D$e t t"e
%mprtan#e ! t"e Pa''%n F&:er %n t"e !&E an- tra-%t%na& me-%#%ne t"%' re'ear#" :a'
#arr%e-2$t :%t" t"e (?e#t%,e t -e,e&p a pr#e-$re !r t"e pr-$#t%n ! -r%e- eHtra#t' !
Passiflora alata Dr)an-er 6pa''%n !&:er7. T"e -r)%nC te't' :ere #arr%e- $t %n t: -%'t%n#t
-r)%nC pr#e''e'9 t"e #n,ent%na& 'p$te- (e- an- t"e 'pra) -r)%nC. T"e (?e#t%,e :a'
t"e %-ent%!%#at%n ! t"e m't ,%a(&e te#"n&C) t per!rm t"%' perat%n.
Passiflora alata Dryander
F%C$re / * S#"emat%# F&:'"eet ! t"e
(tent%n ! t"e ")-r2a&#"&%# an-
#n#entrate- eHtra#t'.
REFERENCES REFERENCES
T"e a$t"r' a#En:&e-Ce FAPESP !r !%nan#%a& '$pprt.
Dr)%nC ED$%pment'9 6a7 Spra)2-r)er SD21G 2 6(7 Sp$te- Be- Dr)er.
T"e me#"an%'m' %n,&,e- n t"e -r)%nC ! t"e !&$%- eHtra#t ! P. alata are '":e- n t"e %maCe' (e&:9
#'()), *., Ftpr%nt' ! t"e Fre't, =aIapr Et"n(tan) 2 t"e H%'tr%#a& E#&C) ! P&antUt%&%8at%n () an
Ama8n%an Pep&e, Columbia +niversity Press, ,ew -ork, .//0.
+1), 2.'. C34, Han-(E ! <e-%#%na& Her(', )d. C3C Press #oca 3anton, 4(, ./56.
6 .7 .6 87
7
.7
87
97
07
67
:7
;7
57
/7


D

(

%

)
W
s
( g/min )
<pouted bed & *g = .,57 m
9
>min
<pray ryer & *g = 7,;9 m
9
>min
<pray ryer & *g = .,78 m
9
>min
Ta(&e / 2 Operat%na& #n-%t%n' $'e- n t"e
-r)%nC eHper%ment'.
T"erma& -eCra-at%n rate ! t"e !&a,n%- #ntent9
The degradation rate of the flavonoid content was obtained by the calculation of the ? decrease of the flavonoid
content in the dried extract related to flavonoid content in the fluid extract.
F%C$re B 2 T"erma& -eCra-at%n ! t"e !&a,n%- #ntent 6'&%-J F1KCL penJ//GKC an- :%t" &%neJ/G1MC7.
Part%#&e '%8e -%'tr%($t%n9
etermination of particle size were performed using an optic microscope and analyzed by the software @mage Pro
Plus !.///".
F%C$re 0 2 SE< p"tm%#rCap"' ! t"e -r%e- eHtra#t' 6N 41117
The dried extract showed low moisture content.
@t was not observed any variation in the particle diameter. The mean diameter was .6m.
The degradation rate of the flavonoid content was between 85 e :;?.
The obtained powder showed high stability and good pharmaceutical properties.
' high flavonoid degradation rate was observed in several operating conditions of the
dryers. Aowever, this problem can be solved by the optimization of the drying parameters.
The spouted bed dryer showed better than the spray dryer in all parameters analyzed.
The spouted bed dryer process showed to be a viable alternative technology for the
production of dried extracts of Passiflora alata ryander and of others medicinal plants.
T"e -r%e- eHtra#t :a' #"ara#ter%8e- ()9
Bm%'t$re #ntent * ,en met"-L
B!&a,n%- -eCra-at%n rate * 'pe#trp"tmetr)L
B'%8e -%'tr%($t%n * m%#r'#p) 6I<AGE PRO2
PLUS
O
%maCe ana&)8er7L
Bpart%#&e ana&)8e * mrp"&C%#a& ana&)8e'
S#ann%nC E&e#trn <%#r'#p).
F%C$re 4 2 S%8e -%'tr%($t%n ! t"e (ta%ne- -r%e- eHtra#t'.
<rp"&C%#a& ana&)8e' ! t"e (ta%ne- -r%e- eHtra#t9
The photomicrographs of the dried extracts were taken with a <canning )lectron Cicroscope at a magnification of
9777 times.
(b) spouted bed dryer
(b) (a)
(a) spray-dryer
7 .7 87 97 07 67 :7 ;7
7,7
7,8
7,0
7,:
7,5
.,7


. 5
8 /
9 .7
0 ..
6 .8
: .9
; .0 C
u
m
u
la
tiv
e
d
ia
m
e
te
r fr
a
c
tio
n
!
&
"
Particle diameter !m"
Spouted bed
Spray-dryer Spray-dryer
Spouted bed