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(Metformin)
BENCLAMET
(Metformin)
• Belongs to the class of drugs called
Biguanides
Variables Effects
Bodyweight Decrease
BPNo effect
Triglycerides Decrease to neutral
Total Cholesterol Decrease to neutral
LDL Decrease to variable
HDL Increase to variable
Lipoprotein(a) Decrease
Hypercoagulability Decrease
C-Reactive Protein Decrease to variable
Endothelial function Improve
Cardiovascular Events Decrease
Indication
• Drug of first choice in obese with type-2
diabetes mellitus.
• USFDA approved in children > 10 years
of age with type-2 DM.
• Metabolic Syndrome.
• Renal disease.
Warnings &
Precautions
• Hypoglycemia may occur.
• Loss of control of blood glucose is seen when patient
is exposed to stress, infection or surgery.
• Should not be used in pregnancy, nursing mothers
and children.
Drug Interactions
• Hypoglycemic action is potentiated with
NSAID’s, salicylates, sulfonamides,
chloramphenicol, & beta blockers.
COMPOSITION
Each tablet contains :
Glipizide 5 mg/10 mg in a SR form
INDICATION
• Type 2 Diabetes Mellitus
GLYTOP-SR
RATIONALE
• Longer acting agents like glibenclamide are
efficacious but have
1) Higher rates of hypoglycemia
PHARMACOKINETICS
• Tmax : 6-12 h
• Steady state : 5th day
6-7 days in elderly
• Effect of food : None
• Metabolism : Liver (90%)
• Excretion : Urine and feces
GLYTOP-SR
DOSAGE
Initial
No fixed dosage regimen
Recommended starting dose : 5mg OD with breakfast
Maximum : 20mg OD
Switch from conventional Glipizide
Nearest equivalent dose
Switch from other SUs
Start with 5mg OD
Type 2 DM Patients on Insulin
<20 units - discontinue insulin, start with 5mg OD Glytop-SR
>20 units -Reduce insulin dosage by 50% and start 5mgOD Glytop-
SR.
GLYTOP-SR
COMPETITION
vs. Conventional Glipizide
COMPETITION
vs. Glibenclamide