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INFRARED SPECTROSCOPY
It is a rapid, nondestructive method of
quantitative and qualititative evaluation of tablet.
It has been used in food and agriculture
industries for many years to determine moisture,
protein and starch.
In Pharmaceutical application, NIR is used as a
secondary analytical tool.
The NIR region of the electro spectrum is from
800 to 2500 nm.
In the NIR region, the radiation can penetrate
compressed materials such as tablets, providing a
vast amount of the information about the sample
Application:
Raw material identification:
It is useful analysis of raw material and final product.
Measure large variation in moisture content and
particle size which is monitored by it.
Used as an identification method
Particle size
Convention methods are sieve method and laser
scattering.
NIR method is used to determine particle size of the
pure granules.
Based on that, the reflectance increase as the particle
size decease.
This method is accurate for larger size particles (above
85 mm).
Employed for MCC and lactose monohydrate.
Moisture content:
Classical method for this is Karl Fischer titration,
gas chromatography, and loss on drying.
In this method presence of the water can be
identified by abs band at 1920-1950nm.
This band depend on the degree of the hydrogen
bond, so as the stronger the bond longer the wave
length of NIR absorption.
And the second band is appearing at 1450nm for
bound water.
This method is used for determination of content
of powder, bulk hard gelatin capsules, and tablets.
Product evaluation:
Tablet coating
Used to determine tablet coating and core thickness.
Used to monitor film coating.
Also used to predict coating thickness of coating
formulation at various intervals during the process and it is
less time consuming.