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TERATOGENIK
PENDAHULUAN
Pemberian obat-obatan kepada ibu
hamil perubahan-perubahan
fisiologik N pe volume
plasma, perubahan motilitas
gastrointestinal dan perubahanperubahan dlm komponen plasma,
fungsi ginjal
TERATOGENESIS
Defek fetus, malformasi,
deformasi, disrupsi.
Malformasi perubahan
embrionik dlm morfognesis
disebabkan proses
perkembangan intrinsik abN.
DEFINITION
Contraindicated in pregnancy
There is no reason to risk use of the drug in pregnancy
Unrated
Ayclovir
Famcyclovir
Vala\cyclovir
CORTICOSTEROISD
MISCELLANEOUSOTHER DRUGS
Benzoyl peroxide
Tretinoin (except first trimester)
MISCELLANEOUSTOPICAL ANTIACNE
PRODUCTS
ANALGESICS
ANESTHETICS
Acetaminophen
Codeine (low dose)
Meperidine (low dose)
Morphine (low dose)
Oxycodone (low dose)
Pentazocine (low dose)
Propoxyphene (low dose)
Bupivacaine (low strength)
Lidocaine
Lidocaine with epinephrine
Lidocaine-prilocaine
Mepivacaine
ANTIBACTERIAL AGENTS
ANTIFUNGAL AGENTS
ANTIFUNGAL AGENTS
contd
Bacitracin-topical
Cephalosporins
Erythromycins
Erythromycin-topical
Penicillins
Sulfur-topical
Sulfur with resorcinol-topical
Tetracycline-topical
Butoconazole-topical
Ciclopirox-topical
Clotrimazole-topical
Econazole-topical
Miconazole-topical
Naftifine-topical
Nystatin-oral and topical
Oxiconazole-topical
Sulconazole-topical
Terbinafine-topical
ANTIHISTAMINES
ANTIVIRAL AGENTS
Acyclovir
Valacyclovir
ANTISCABETIC
AGENTS
Crotamiton-topical
CORTICOSTEROIDS
MISCELLNEOUSTOPICAL ANTIACNE
MISCELLANEOUSOTHER DRUGS
Allopurinol
Calcipotriene-topical
Hydroquinone-topical
Masoprocol-topical
Methoxsalen-topical
Flutamide
Estrogens
Isotretinoin
Etretinate
Finasteride
Stanozolol
Fluorouracil
CATEGORY D
Azathioprine
Bleomycin
Colchicines
Cyclophosphamide
Griseofulvin
Hydroxyurea
Mechlorethamine
Penicillamine
Potassium iodide
Spironolactone
Tetracycline
UNRATED
ADVERSE EFFECTS
CRITICAL
PERIOD
Maternal Conditions
Diabetes
Hypothyroidism /
Hyperthyroidism
Phenylketonuria (PKU)
Hyperthermia
Systemic lupus
erythematosus (SLE)
Entire
pregnancy
2-4 weeks
TERATOGEN
ADVERSE EFFECTS
CRITICAL
PERIOD
Nonprescription
Substance Use
Alcohol
Entire
pregnancy
Tobacco
Unknown
Toluene
Unknown
TERATOGEN
ADVERSE EFFECTS
CRITICAL
PERIOD
Medications
Aminopterin /
methotrexate
14-69 days
Amiodarone
Second-third
trimester
ACE inhibitors
Oligohydramnios, renal
dysplasia/failure, IUGR, joint
contractures, prenatal death
Second-third
trimester
Carbamazepine
14-60 days
TERATOGEN
Cyclophosphamide
ADVERSE EFFECTS
CNS defects, skeletal defects
(especially cranial and digits),
IUGR cleft palate, neonatal
death
CRITICAL
PERIOD
14-60 days
Indomethacin
Oligohydramnios, anuria,
necrotizing enterocolitis,
premature ductus arteriosus
closure
Second-third
trimester
TERATOGEN
ADVERSE EFFECTS
CRITICAL
PERIOD
Lithium
14-60 days
Methylene blue
Jejunal atresia
Second
trimester
Misoprostol
Firstsecond
trimester
Penicillamine
14-60 days
ADVERSE EFFECTS
CRITICAL
PERIOD
Phenytoin
14-60 days
Retinoids
(isotretinoin,
acitretin)
Unknown
Selective serotonin
reuptake inhibitors
(SSRIs)
Prenatal complication,
increase in minor
anomalies
Third
trimester
TERATOGEN
TERATOGEN
ADVERSE EFFECTS
CRITICAL
PERIOD
Tetracycline
Staining of primary
dentition
Secondthird
trimester
Thalidomide
27-40 days
Trimethoprim
First
trimester
TERATOGEN
ADVERSE EFFECTS
CRITICAL
PERIOD
Medications-contd
Trimethadione
14-60 days
Valproic acid
14-60 days
Warfarin