Rizka Annur Putri

I21111039

All mechanisms used by our body to

maintain integrity of the body as a
protection against hazards that may be
incurred in the various materials

action of the body to be able to recognize

whether a substance is foreign (non-self)
or not (self) to the body

Complement
CRP
Cytokine
Antibody

Complement is a group of protease in a

serum which complement serums activity
in bacteria or cell lysis

An acute phase protein; group of protein

which is increasing in blood when acute
infection happens

Cytokine is group of peptide which is

produced by immunocompetent cell and
plays a role in reducing or increasing
immune system

Pleiotropi
(efek pada lebih dari 1 jenis
sel)

langsun
g

Autoregulasi (fungsi
autokrin)
Fungsi parakrin

Sitokin
Tak
langsun
g

Sinergisme: Induksi ekspresi reseptor

untuk sitokin lain, bekerjasama dengan
sitokin lain
Antagonisme : Mencegah
ekspresi reseptor atau produksi
sitokin

group of glycoprotein which is produced

by plasma cells in response to certain
foreign configuration
It can bind to the antigen, complement, or
receptors
on
the
surface
of
immunocompetent cells
Antibody can increase the effectivity of
antigen elimination

Phagocytes
NK Cell
Lymphocytes

Cells which attract (using chemotaxis),

attached to, swallow, and digest foreign
materials
Include macrophage

NK cell is granular lymphocyte which can

recognize infected surface glycoprotein cell
and kill that cell.
Its circulating in the blood and lymph to lyse
cancer cells and virus-infected cells.
The number of NK cells around 5-5% of
lymphocyte in blood and 45% of lymphocyte
in tissues.
These cells have function in nonspecific
immunity against viruses and tumor cells.

Lymphocytes are cellular components of

the immune system that is specific to the
antigen through receptor structures on the
surface of immunocompetent cells.
Lymphocytes are divided into two, namely
T and B lymphocytes

it differentiates from thymus gland

besides as immunocompetent cells, T
lymphocytes also play a role as a
regulator in the bone marrow, whether the
body will respond in humoral or cellular.

It differentiates in Bursa Fabricius for aves

and in gut associated lymphoid tissue
(GALT) for other vertebrates.
B lymphocytes play a role in humoral
immune system therefore they will be able
to differentiate into plasma cells which can
generate specific antibodies.

Nonspecific immunity acts as first line of

defense against infectious agent, which
pathogen will be destroyed before it
proliferates and causing infection.
If this defense doesnt work well, specific
immune system will be activated.
Healing through a specific immune
response will leave specific immunological
memory so that subsequent infection with
the same infectious agent will not cause
disease