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FLUID THERAPY
Body Weight
70 kg
60%
40%
66%
Intracellular fluid
(ICF)
28 liters
33%
Extracellular fluid
(ECF)
14 liters
Plasma
3 liters
Physiology
body
potassium
is
within
the
intracellular
anions
in
interstitial
fluid
compared
to
Crystalloids
Colloids
haemoglobin
concentration
in
the
circulating
Fluid therapy
Fluid warming
Blood components
1. Blood. Fresh blood is less than 5 days old. It is rich in clotting factors
and platelets. It is inefficient to store blood as whole blood. Most
patients will require red cells only and the separation off of platelets and
plasma allows these products to be targeted at the needs of individual
patients. The shelf life of whole blood is shorter than packed cells. There
is more microaggregate formation and a higher risk of haemolysis and
GvHD because of larger amounts of plasma and white cells. Packed cells
have a haematocrit of 0.5-0.6.
Leukocyte depleted red cells are indicated in patients with a history of
non-haemolytic febrile transfusion reactions (NHFTR) which are due
usually to recipient antibody to donor white cells. Following theoretical
concerns about the transmission of prions in white cells, all donated
blood in the UK is now leukocyte depleted.
Frozen red cells are used for rare blood groups or autologous storage in
large amounts.
in
fibrinogen
deficiency/depletion,
hyperkalaemia.
Blood transfusion
Causes of anaemia in the critically ill I
Compatibility testing
Complications of blood transfusions
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