Vanillin from G

Names of team members, roll no,

etc.

Vanillin
Vanillin is a phenolic aldehyde.
It is primarily extracted from vanilla bean.
Synthetic vanillin is used more often as a flavouring
agent and pharmaceuticals. It is due to cost factor,
high profit margin and scarcity of naturally available
vanillin compared to the demand.
The first commercial synthesis of vanillin began with
the more readily available natural compound
eugenol.
Today, artificial vanillin is made either fromguaiacol
or fromlignin or other biotechnological methods like
rice straw or wheat grass..etc

Various Synthetic routes of Vanillin

from Guaiacol

Outline of the Process

OH

OH

OH

OCH3

OCH3

OCH3

Air/Co(OAc)2

HCHO/ IER

AcOH

AcOH

CHO
OH

H2O

Quick Review of physical

props
mp

bp

Solubility in
water

MoC

Guaiacol

27 - 32 C

205 C

17g/L (15 C)

SS-304

Acetic Acid

16 - 17 C

118 - 119
C

Readily
soluble in
cold, hot
water

SS-304

Paraformaldeh
yde

120 - 170
C

P-Vanillyl
alcohol

112 - 115
C

Cobalt Acetate

500mg/L (18
C)
SS-304

Decompos
Readily
es at
soluble in
Want some
more columns like suitable
MoC for
100C
cold water
storage, molar
Vanillin
80 Cratio used
285inCbatch.11 g/L (25 C) SS-304

Process Flow Diagram

i)
ii)
iii)
iv)

AcOH
Guaiacol
Amberlyst-15
Paraformaldehy
de

Hydroxymethylation
Filter Amberlyst-15

i) Co(OAc)2
ii) Air

Oxidation

Distillation

Amberlyst - 15

AcOH

Water

Molten Vanillin +
Catalyst

Dissolving catalyst in
minimum amount of water

Layer seperation

Fractionation

Vanillin

Aqueous Layer (Cataly

Equipment Flow Sheet

AcOH (SS304)

Guaiacol (SS-304)

Cobalt
Acetate

Paraformaldehyd
e
Amberlyst15
SS-304 Reactor
Mesh Filter SS304
Air
SS-304
Autoclave
Catalyst + AcOH+
Vanillin

water (HDPE)

AcOH+water
+traces of
HCOOH
Condensing
steam

Aqueous Layer
+ catalyst

Vanilli
n
SS304

PP-FRP

SS-304
Fractionation
assembly

Costing and Economics

Chemical

Molar
basis

Weight/Volu
me

Cost

Total cost

Guaiacol

0.124 kg

318 Rs/kg

39.432 Rs

Para1.05
formaldehyd
e

0.0315 kg

85 Rs/kg

2.6775 Rs

Glacial
acetic acid

0.3 lit (0.3147 45 Rs/kg

kg)

14.16 Rs

Amberlyst15

0.015 kg

1000
Rs/kg

15 Rs

Cobalt
acetate
tetrahydrate

0.00249 kg

510 R/kg

1.27 Rs/kg

Methanol
Water
Toluene

35 Rs/kg

Assuming recovery
Chemical Weight/
Volume
Acetic
acid

%
Recover
y

0.3147 kg 85

Amount
recovere
d

Cost per
kg

Cost
recovere
d

0.267 kg

45 Rs

12.03 Rs

Amberlyst 0.015 kg
-15

95

0.01425
kg

1000 Rs

14.25 Rs

Cobalt
acetate
tetrahydr
ate

98

0.00244
kg

510 Rs

1.2445 Rs

Methanol
Toluene
TOTAL

0.00249
kg

Process

Yield

Reference

Hydroxymethylat
ion
Oxidation

Overall yield = Yield of

hydroxymethylation * Yield of oxidation =
1 mole Guaiacol gives
moles of
Vanillin =
kg Vanillin
(Total cost Cost recovered)/(
Vanillin) = Raw material cost =

kg of

Manufacturing cost
Manufacturing cost is assumed to be
35% of raw material cost.
Manufacturing cost = 35% of RMC =
Total cost = RMC + Manufacturing
cost
=