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Wahyu Murtiono.H
Department of Otorhinolaryngology-Head & Neck Surgery
Faculty of Medicine Padjadjaran University
Hasan Sadikin General Hospital
Bandung
2011
Prenatal sensitization
Multifactorial cause of allergy
Genetic constitution Environmental
Factors
* Still in debate.
Postnatal beginning
Inhaled allergen and food allergen.
Exposure to allergen in early life in
genetically predisposed individual.
Airways allergic diseases (allergic rhinitis
and asthma) increased steadily in prevalence
to age 7years.
Dermatitis,
Gastroesophageal reflux,
Chronic rhinorrhea
Recurrent wheezing
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Beneath:
Genomic predisposition
(familial and individual tendency to develop immune
dysregulation under certain environmental
circumstances).
Lawrence D. Rosen, M.D. An Integrative Approach to Atopic Disorders in Children DOI:
10.1089/act.2007.13201
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Genetic factors:
During the first twenty years of life
The risk of developing atopic
symptoms correlated to the existence
of atopic disease in parents and
siblings.
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Allergens:
Food allergens
Respiratory inhaled allergens
(pollen, moulds, animal dander, mites).
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The environment:
Insufficient exposure to certain
infectious agents in early childhood
increase the risk of developing allergy
by disturbing the TH1/TH2 balance and
favouring the TH2 allergic mechanism.
Improved hygiene could be partly
responsible for this phenomenon.
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Th1 immune :
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Adrian Morris, MBChB, DCH, MFGPIS ALLERGY TESTING COST EFFECTIVE? Current Allergy &
Clinical Immunology, March 2006 Vol 19, No.1
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Prevention of atopy
Primary prevention :
The avoidance of early allergen exposure to certain
foods and inhalantsfrom birth.
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CONCLUSIONS
Allergic diseases have now become the
most common group of diseases
among children.Treatment is mainly
based on preventing and/or controlling
symptoms
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THANK YOU
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