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Membrane
integrity
Cell wall
B-lactam
drugs
Polypeptides
drugs
Glycopeptide
drugs
Nucleic
acid
synthesis
Protein
synthesis
Colistin
AntiTetra- Chloroam- MacroAmino
(plymixen Fungal
glycosides cycline phenicol
lides
E)
Drugs
Penicillins
imidazole
Lincosemides
Fusidic
acid
-Ketoconazole(oral)
-Clotrimazole(all
forms)
-Fluconazlo/Itraconazloe
Cephalo
sporins
Carbapenems
Monobactams
triazloe
polyenes
Nystatin
-Oral/topical
-safe
AmphoTercin
B
-systematic infections
-IV mainly
-Toxic
Essential
metabolites
synthesis
Sulfa
-Nalidixic
Quinodrugs
acid
Rifamycin lones
-Nitro Rifampin Fluro- (sulfonafurantion
quinoloes mides)
AntiTuber
culosis
drugs
-Ex:INH+streptomycin
Ethambutol+rifampin
Cell wall
B-lactam
drugs
Penicillins
Penicillin G
Penicillin V
*A*
Ampicillin
Amoxacilllin
*B*
Cephalosporins
First
generation(1960s)
Cephradine
cephaexin
Cephalothin
Second generation
(1970s-1980s)
Cefoxitin
Cefuroxime
Polypeptide
drugs
Carbapenems
Imipenem
Entrapenem
Meropenem
-For Nosocomial
infections
Ticarcillin
carbencillin
Piperacillin
*D*
Fourth generation
(1995)
cefepime
-polyenes
-bacteriocidal
-Broad spectrum
-for
serious/nosocomial
Third generation
(1980s-1990s)
Ceftrazidime
cefotaxime
Ceftriaxone
Aztreonam
-IV/IM
-IV/IM
-Bacetracin
-Colistin
(polymixen B)
-broad
spectrum
-peniciliinase R
Infections
Methicillin
Oxacillin
Cloxacillin
Augmentin
*C*
monobactams
-beaks down
phospholipids
of bacterial
cell membrane
changing
membrane
permeability.
-very
toxic( has side
effects)
-used against:
Pseudomonas
aeruginosa
-used against:
MR-pathogens
&
Acinobacter(ca
using
septicemia)
-nephrotoxic
-oral/topical
except on
Glycopeptides
drugs
Vancomysin
Teicoplanin
-used against:
*ORSA
*MRSA
*Multi Renterococci(E.fecal
is)
*but not gram Ve
bacteria.
-interfere with
enzymes
responsible for
cross linking of
peptidoglycan
layer.
-Inject able not
oral.
-useful in clinical
practice.
Fisrt generation
-similar activity to
ampicillin &
amoxicillin
-decreased usage by
time
-They have narrower
spectrum than other
drugs.
Cephalosporins
Second generation
-broad spectrum
-affect
Facultative
anaerobic
bacteria
-used especially
in surgeries
Third generation
-Mainly against
G-ve bacteria
-They are
expected to be
unavailable in the
next 5 years.
Fourth generation
Penicillin
-Bactericidal
-Affect + Anaerobic/narrow
spec.
-Injected (not orally since
its inactivated by stomach
acids)
-1940-1941
*A*
*B*
*C*
-broad spectrum
Penicillin G
-Narrow
spectrum
-1965
(-Ve)
-Affect facultative
anaerobic bacteria
found in intestine.
Penicillin V
*D*
-mid 70s
-B lactamase
susceptible.
-For nosocomial
infections.
-Bactericidal
-Affect
+Anaerobic/narrow
spec.
*C*
-can be taken
orally (not
inactivated)
-1942-1943
-its a modified
penicillin G
Methicillin
Oxacillin
Cloxacillin
Augmentin
-narrow spectrum(+ve)
-used in laboratory and
Clinical Practise
-used against ampicillin
amoxicillin
Penicllin G,V resistant bacteria
-1960s
-Amoxacillin+clavulanic
acid
-Broad spectrum
-Penicillinase resistant
(due to
The presenece of
Clavulanic acid)
Protein
synthesis
Tuberculosis
Intestinal infection
Meningitis
sepsis
AminoGlysocides
(30s subunit)
streptomycin
Neomycin
Konamycin
Gentamycin
Tobramycin
Netilimycin
Amikacin
TetraCyclines
(30s subunit)
Doxycycline
minocycline
-Broad spectrum.
-Orally or injected
(orally more common)
-Not given to cildren
Under 8
-For Ut/Rt infections
Caused by
mycoplasma
,clamydia and
Legionella.
ChloramPhenicol
(50s subunit)
MacroLides
(5os subunit)
LincoSamides
(50s subunit)
Erythromycin
Clarithromycin
azithromycin
-Broad spectrum
-block peptide bond formation
-For intestinal/skin/respiratory
/CNS infections
Ie:Meningitis /septicemia/thyoid fever/
Aplastic anemia
-can cross the blood brain barrier
Fusidic acid
-applied topically
(creams/eye drops)
-for skin infections
-steroidal/prevent
t-RNA translocation
To ribosomes
-not used in system.
Infections very toxic
-metronidazol(flagyl)
is an example.
Nucleic acid
synthesis
Nalidixic acid
Rifamycin
quinolones
-prevent transcription
by binding to RNA
Polymerase
-Broad spectrum
-effective in killing
IC Bacteria
-used for serious infection
Meningitis /brucellosis
Not for simple RT infection
(WHO)
-Bacteria May produce enzyme
affect B Subunits in RNA
Polymerase Developing
resistance to these drugs
-less toxic then aminoglysocides.
Norfloxacin
UT/RT infections
Ciprofloxacin
UT/RT(pneumonia)/
Intestinal/blood
(septicemia)
infections
Levofloxacin
Upper RT infections