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Prepared for:
Agency for Healthcare Research and Quality (AHRQ)
www.ahrq.gov
Outline of Material
Agency for Healthcare Research and Quality Comparative
Effectiveness Review (CER) Process
Background
Clinical Questions Addressed in the CER
Clinical Bottom Line: Summary of CER Results
Conclusions
Gaps in Knowledge
Resources for Shared Decisionmaking
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
AHRQ Methods Guide for Effectiveness and Comparative Effectiveness Reviews. Available at www.effectivehealthcare.ahrq.gov/methodsguide.cfm.
Owens DK, Lohr KN, Atkins D, et al. J Clin Epidemiol. 2010 May;63(5):513-23. PMID: 19595577.
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm .
Brandt ML. Pediatric hernias. Surg Clin North Am. 2008 Feb;88(1):27-43, vii-viii. PMID: 18267160.
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Example:
Open Mesh-Based Repair of an Inguinal Hernia
Before
After
Mesh
Laparoscope
Mohamed H, Ion D, Serban MB, et al. J Med Life. 2009 Jul-Sep;2(3):249-53. PMID: 20112467.
Robinson TN, Clarke JH, Schoen J, et al. Surg Endosc. 2005 Dec;19(12):1556-60. PMID: 16211441.
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Mohamed H, Ion D, Serban MB, et al. J Med Life. 2009 Jul-Sep;2(3):249-53. PMID: 20112467.
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Outcomes of Interest
Outcomes
Hernia recurrence
Hospital-related information
(length of hospital stay and
hospital/office visits)
Return to daily activities
Return to work
Quality of life
Patient satisfaction
Short-term pain (1 month
after surgery)
Intermediate-term pain (>1
and <6 months after surgery)
Long-term pain (6 months
after surgery)
Adverse effects
Infection
Perception of a foreign body
Small-bowel
perforation/obstruction
Hematoma
Epigastric vessel injury
Urinary retention
Spermatic cord injury
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Outcome
Surgery
Favored
Calculated Differences
(95% CI)
Hernia recurrence
Open surgery
Low
Length of hospital
stay
Approximate
equivalence
Return to normal
daily activities
Laparoscopic
High
Return to work
Laparoscopic
High
SOE
Low
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Outcome
Surgery
Favored
Calculated Differences
(95% CI)
SOE
Long-term pain
Laparoscopic
Moderate
Epigastric vessel
injury
Open
Low
Hematoma
Laparoscopic
Low
Wound infection
Laparoscopic
Moderate
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Outcome
Surgery
Favored
SOE
Return to daily
activities
Laparoscopic
High
Long-term pain
Laparoscopic
Moderate
Re-recurrence
rates
Laparoscopic
(TAPP or TEP)
Low
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Gaps in Knowledge
How the surgeon's experience influences surgical outcomes
such as recurrence and pain
The comparative effectiveness and adverse effects of
laparoscopic repair versus watchful waiting for pain-free or
minimally symptomatic inguinal hernias in adults
The comparative effectiveness and adverse effects of
contralateral exploration/repair versus watchful waiting in the
pediatric population
More evidence on several outcomes related to the comparisons
of mesh products and fixation methods including recurrence
rates, perception of a foreign body, long-term pain, and
infection rates
Clarification in future studies of whether the population
includes emergent as well as elective surgeries and whether or
not the findings apply equally to both populations
Treadwell J, Tipton K, Oyesanmi O, et al. AHRQ Comparative Effectiveness Review No. 70. Available at
www.effectivehealthcare.ahrq.gov/inguinal-hernia.cfm.
Shared Decisionmaking:
What To Discuss With Your Patients
If repair or watchful waiting is the right decision for their
pain-free or minimally symptomatic inguinal hernia
How to choose between open or laparoscopic surgery if
the option is available
What to expect from open or laparoscopic repair as far as
outcomes and adverse effects, including the risk of longterm chronic pain
What to do if the hernia recurs