Salbutamol

Salbutamol
Drug name (generic):

Salbutabol
Therapeutic class:

Bronchodilator Agent
Adrenergic betaAgonists
Tocolytic agent
Pharmacological class:
Sympathomimetic (beta2-adrenergic
agonist)

Chemical name (IUPAC):

4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol

Chemical structure:

Empirical formula:
C13H21NO3
Pregnancy category: C

Physical
properties:

Odour :
Odourless

Solubilty:
Sparingly soluble in water; soluble in ethanol
(96%); slightly soluble in ether.

Colour:
A white or almost white, crystalline powder

Pharmacodynami
c

Salbutamol is a short-acting, selective beta2adrenergic receptor agonist used in the

treatment of asthma andCOPD.
Salbutamol is formulated as a racemic mixture of the
R- and S-isomers.

S-isomer:
R-isomer:

Mechanism of
Action

Salbutamol is a beta(2)-adrenergic agonist and thus it

stimulates beta(2)-adrenergic receptors.

Salbutamol increases cAMP production by activating

adenylate cyclase.

Increased intracellular cyclic AMP increases the

activity of cAMP-dependent protein kinase A, which
inhibits the phosphorylation of myosin and lowers
intracellular calcium concentrations.

Mechanism of
Action
A lowered intracellular calcium concentration leads to
a smooth muscle relaxation and bronchodilation.

Increased cyclic AMP concentrations are also inhibits

the release of bronchoconstrictor mediators such as
histamine, leukotreine from the mast cells in the
airway.

Pharmacokinetic
s

Pharmacokinetics
Bioavailability :
oral bioavailability 50%
Half life :
half life is 4 hours
(Taken from rang & dell page 168)

Onset of Action:
oral: 30 minutes, Inhalation : 5-15 minutes
Duration of action :

(page 361 R&D)

8 to 12 hours

Metabolism :
It is subject to first pass metabolism in the liver

Pharmacokinetics
Exretion :
Readily excreated in the urine as
metabolite and unchanged drug
Some excreate in faeces.

Reference
Martindale 35th edition page 1016

Clinical uses and

Side Effects

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Female reproductive
system
Relaxation of uterus
(during pregnancy)

Reference
From nurses drug hand book page 37

Drug Intrections

Contraindication
& precaution

Doses
Acute bronchospasm:
1 or 2 inhalation of salbutamol i.e 100
microgram 3 or 4 time daily
Severe attack of bronchospasm:
250 microgram i.v insolution form 10
microgram/ml
Premature labour.
I.V infusion 200 microgram with 5% gluse
used for dilution.

Products for Salbutamol

available in market

Brand name

Manufacturer
Name

Dosage Forms

Ventoline

GSK

Injection: 0.5 mg
Syrupe: 60 ml
Tablet : 8 mg

Respoline

Munawar pharma

Tablet : 2 mg

Aeroline

Ankaz

Syrupe : 60 , 450 ML
Tablet : 2 , 4 MG

Salbutamol

Nawab sons

Syrupe : 60 ML

Asmatol

Siza

Injection : 0.5 MG
Tablets : 4 MG

Ventomol

Venus

Tablets : 2 & 3 MG

Reference
Taken from martindale 35th edition page 1016

Reference
Pharmaguid page # 1159

Thank you