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Etiology
Microorganism and condition that may predispose to infection
Microorganism
Condition
Gram-negative bacteria:
Diabetes mellitus
Lymphoproliferative diseases
Cirrhosis of the lever
Burns
Invassive procedures or devices
Neutropenia
Indwelling urinary catheter
Diverticulitis, perforated viscus
Gram-positive bacteria:
Staphylococcus aureus, coagulase-negative
staphylococcus, enterococci, Streptococcus pneumoniae,
other streptococci, other gram-positive bacteria
Fungi
Polymicrobial
Classic pathogens:
Neisseria meningitidis, S. pneumoniae, H. influenzae,
Streptococcus pyogenes
Intravascular catheter
Indwelling mechanical devices
Burns
Neutropenia
Intravenous drug use
Infection with superantigen-producing S. pyogenes
Neutropenia
Broad-spectrum antimicrobial therapy
Epidemiology
The relatively high frequency with which sepsis develops in pts with AIDS
Merusak organ
(e.g. ARDS)
Temuan penelitian:
G-CSF
produksi nuetrofil
survival
Otopsi
?
cell hibernation
(cell stunning)
Bakteri
Apoptosis
Survival
PARP - inhibotor
Kesimpulan