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Sistem Pencernaan
Hati dan pankreas
Learning Objective
1. Explain the functions of liver.
2. Explain the functions of gallblader.
3. Explain the functions of pancreas.
Liver
Largest internal organ
Receives major blood supply from hepatic portal vein
Brings venous blood rich in nutrients from digestive tract
Hepatocytes
Livers cells
Capable of regeneration
Liver
Liver
Functions
1. Metabolic regulation
1.
2.
3.
4.
5.
6.
7.
Carbohydrate metabolism
Lipid metabolism
Amino acid metabolism
removal of waste products
Vitamin storage
Mineral storage
Drug inactivation
Liver
Functions
2. Hematological regulation
1.
2.
3.
4.
5.
6.
Liver
Functions
3. Circulatory regulation
4. Growth regulation
Synthesis:
42%
Hidrostatic P,
Fenestrae,
trans endotel
lymphatic drainage
Insulin
GH
Feeding
Skin
41%
Muscle
40%
Gut
7%
Liver
3%
Subcutaneous, etc. 9%
Gallbladder
Attached to surface of the liver
Bile pouch that stores bile
Ducts
Hepatic Duct
Cystic Duct
Common Bile Duct
Gallbladder
Function:
Bile storage
Bile modification
Bicarbonate secretion
Bile compasition
Water
Bilirubin
Ion
Cholesterol
Bile salt
Bile Secretion
Necessary for digestion and absorption of lipids in small
intestine
Mixture of bile salts, bile pigments, and cholesterol
Bile salts emulsify lipids to prepare them for digestion
Solubilize products of lipid digestion in packets called
micelles
Pancreas
Exocrine and Endocrine Gland
1. ExocrineAcinar Cells
2. EndocrineIslets of Langerhans
Pancreas
Pancreas
Pancreatic Secretion
Exocrine pancreas secretes ~1 L/day into duodenum
Fluid consists of HCO3- and enzymes
HCO3- neutralizes H+ delivered to duodenum from stomach
Enzymatic portion digests carbohydrates, proteins, and lipids into
absorbable molecules
Acinar Cells
Ductal Cells
HCO3- Secretion
Pancreatic Endocrine
Somatostatin
Kadar somatostatin
plasma meningkat dari
112 mjd 182 pmol/l
setelah makan