ANS-Receptors Overview - MIS

Receptors and signal transduction in the

ANS
Cholinergic Receptors

Nicotinic

Ganglionic

Skeletal
Muscle

Muscarini
c

Neuronal
CNS

Receptors and signal transduction in the

ANS:
Nicotinic Receptors

ACH

Na+

ACH

Receptors and signal transduction in the

ANS:
Nicotinic Receptors
NH 3

ACH

Na+

ACH

COOH

Receptors and signal transduction in the

ANS
Cholinergic Receptors

Nicotinic

Muscarinic

M1

M3

M5

M2

M4

Receptors and signal transduction in the

ANS:
Muscarinic receptors are 7 transmembrane domain,
G-protein coupled receptors

Receptors and signal transduction in the ANS:

Muscarinic
NH3 receptors
(M1, M3, M5)

Gq

(+) Phospho-

lipase C
PIP2

COOH

IP3

Diacylglycerol

Increase Ca2+

Activate Protein
Kinase C

Response

Receptors and signal transduction in the

ANS:
Muscarinic
Receptors
NH 3
(M2 and M4)

(-)

Adenylate Cyclase

GI

K+

(+)
COOH

ATP

cAMP

Reduce cAMP-Dependent
Protein Kinase Activity
Response

Receptors and signal transduction in the

ANS
Adrenergic Receptors

1
1A

1B

2
1D

2A

2B

2C

Receptors and signal transduction in the ANS:

1NH
-Adrenergic
3
Receptors

Gq

(+) Phospho-

lipase C
PIP2

COOH

IP3

Diacylglycerol

Increase Ca2+

Activate Protein
Kinase C

Response

Receptors and signal transduction in the ANS:

-Adrenergic
NH2
3
Receptors

(-)

Adenylate Cyclase

GI

K+

(+)
COOH

ATP

cAMP

Reduce cAMP-Dependent
Protein Kinase Activity
Response

Receptors and signal transduction in the ANS:

-Adrenergic
NH 3Receptors

(+)

Adenylate Cyclase

GS

COOH

ATP

cAMP

Increase cAMP-Dependent
Protein Kinase Activity
Response

Functional Responses Mediated by the ANS

Effector Organ
Heart

Rate of Contraction
Force of Contraction

Adrenergic
Response
Increase
Increase

Receptor
1
1
,

Cholinergic
Response
Decrease
Decrease

Receptor
M2
M2

Functional Responses Mediated by

the ANS
Effector Organ

Adrenergic
Response

Arteries (most)
Veins
Skeletal Muscle
Endothelium

Vasoconstriction
Vasoconstriction
Vasodilation
----------

Cholinergic
Receptor Response
1
2
2
--

---------------------------Release EDRF

Receptor
---M3

Functional Responses Mediated by

the ANS
Effector Organ

Adrenergic
Response

Cholinergic
Receptor Response

Receptor

Lung
Bronchiolar
smooth muscle

Bronchodilation

Bronchoconstriction

M3

Functional Responses Mediated by

the ANS
Effector Organ

Adrenergic
Response

Cholinergic
Receptor Response

Receptor

Genitourinary, smooth muscle

Bladder wall
Ureter
Sphincter
Uterus (pregnant)
Penis/vas deferens

Relaxation
Contraction
Contraction
Relaxation
Contraction
Ejaculation

2
1
1
2
1
1

Contraction
Relaxation
Relaxation
Variable
Erection

M3
M3
M3
M3
M3

Functional Responses Mediated by

the ANS Cholinergic
Adrenergic
Effector Organ

Response

Receptor Response

Receptor

Gastrointestinal Tract
Salivary Glands
Smooth Muscle:
Walls
Sphincters
Secretion

Increase secretion
Relaxation
Contraction
----------

1
2 , 2
1
--

Increase secretion

M3

Contraction

M3
M3
M3

Relaxation
Increase secretion

Functional Responses Mediated by

the ANS
Effector Organ

Adrenergic
Response

Cholinergic
Receptor Response

Receptor

Skin
Contraction,
Piloerection

--------------

--

Thermoregulation

Increase secretion

M3

--------------

--

Apocrine (stress)

Increase secretion

--------------

--

Hair follicles,
Smooth muscle

Sweat glands

Functional Responses Mediated by

the ANS
Effector Organ

Adrenergic
Response

Cholinergic
Receptor Response

Receptor

Eye
Iris
Radial muscle

--------------

--

-------------

1
--

Contraction

Ciliary muscle

[Relaxation

2]

Contraction

M3

Ciliary epithelium

Increase secretion
of aqueous humor

--------------

Circular muscle

Contraction

M3
--

Physiology of the eye

Canal of
Schlemm
Trabecular
meshwork

Radial
muscle ( 1)

Circular
muscle (M3)

Iris
Lens
Ciliary
muscle (M3)

Ciliary
epithelium ( 2)

Physiology of the eye

Physiology of the eye

Circular muscle
(M3 Receptors)

Pupil

Physiology of the eye

Contraction of circular
muscle leads to
miosis

Pupil

Physiology of the eye

Contraction of circular
muscle leads to
miosis

Pupil

Physiology of the eye

Radial Muscle
( 1 Receptors)

Pupil

Physiology of the eye

Contraction of radial
muscle leads to
mydriasis

Pupil

Functional Responses Mediated by

the ANS
Effector Organ

Adrenergic
Response

Cholinergic
Receptor Response

Receptor

Metabolic functions
Liver

Glycogenolysis
Gluconeogenesis

1, 2

--------------

--

Fat cells

Lipolysis

--------------

--

Kidney

Increase renin
secretion

1, 3
1

--------------

--

Pancreas

Decrease insulin
release

--------------

--