Documente Academic
Documente Profesional
Documente Cultură
Medicinal
Chemistry
Pathophysiology
Therapeutics
ANS
Disease State
Management
Pharmacology
Sympathetic
Parasympathetic
Copyright 2005
Figure 15.3
Copyright 2005
Pearson Education,
Inc., publishing as
Benjamin
Cummings
Figure 15.7
Figure 15.4a
Figure 15.4b
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Parasympathetic Ganglionic Synapse
Ca 2+
Acetylcholinesterase
Na+
ACH
Action Potential
Na
Preganglionic neuron
Nicotinic
Receptor
Postganglionic neuron
MCMP 407
Parasympathetic Organ Synapse
Acetylcholinesterase
Ca 2+
Effector
Organ
Na+
K+
G
Action Potential
ACH
Muscarinic
Receptor
Postganglionic neuron
MCMP 407
Summary of parasympathetic neurons
and synapses
Preganglionic neurons
Long
Synapse with postganglionic neurons at or near organ
Release acetylcholine (ACH) to activate nicotinic receptors on
postganglionic neurons
Postganglionic neurons
Short
Synapse on the target organ
Release acetylcholine (ACH) to activate muscarinic receptors on
the target organ
MCMP 407
Sympathetic Ganglionic Synapse
Ca 2+
Acetylcholinesterase
Na+
ACH
Action Potential
Na
Preganglionic neuron
Nicotinic
Receptor
Postganglionic neuron
MCMP 407
Sympathetic Organ Synapse
Ca 2+
Effector
Organ
Na+
Action Potential
G
NE
Adrenergic
Receptor
Postganglionic neuron
MCMP 407
Summary of sympathetic neurons
and synapses
Preganglionic neurons
Short
Synapse with postganglionic neurons near spinal cord
Release acetylcholine (ACH) to activate nicotinic receptors on
postganglionic neurons
Postganglionic neurons
Long
Synapse on the target organ
Release norepinephrine to activate adrenergic receptors on target
organs
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Exceptions in the sympathetic nervous system:
Sweat glands:
Postganglionic neurons
involved with stress-related
excretion release
norepinephrine (sweaty
palms)
Postganglionic neurons
involved with
thermoregulation release
acetylcholine
MCMP 407
Exceptions in the sympathetic nervous system:
Kidneys:
Postganglionic neurons to the
smooth muscle of the renal
vascular bed release dopamine
Adrenal gland:
Preganglionic neurons do not
synapse in the paraverterbral
sympathetic ganglion
Preganglionic neurons synapse
directly on the adrenal gland,
release acetylcholine, and
activate nicotinic receptors on
the adrenal gland
Adrenal glands release
epinephrine into systemic
circulation
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How do drugs influence the ANS?
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