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2.
Know the basic structures of every macromolecules (YES, you will be asked to
DRAW in the exam)
Simple reactions & mechanisms (YES, you have to review your ORGANIC
CHEMISTRY II)
Be able to synthesize those info into a logical whole the big picture
Discover how the concepts presented impact your health, environment & the
biological world
Live your life: eat well, play sports, jog, drink well and understand the
biochemistry behind all of these processes
Study when you are rested, alert and have planned for it. Last minute usually
is a waste of time.
Come to class: regular class attendance is essential for success especially for
BIOCHEMSITRY
Take note: take your own note pick up the important clues in class
Form a study group: good practice for this class, your university study,
science career & future
Keep up
Heme
Precursor
Hydrophobicity vs Hydrophilicity
This effect is critical for the folding of proteins & self-assembly of biological
membranes
Hydrophobicity vs Hydrophilicity
Points to note:
Ions are easy for water to solvate around because they are charged
2.
3.
Because of the uneven distribution of charge in O-H bonds and their angled
arrangement, the water molecule has a permanent dipole
2.
Water molecules can form hydrogen bonds with each other. Hydrogen bonding
contributes to the high specific heat and heat of vaporization of water
3.
Because it is polar, water can dissolve crystalline electrolytes. Water molecules form
a solvation sphere around each dissolved ion. Organic molecules may be soluble in
water if they contain ionic or polar functional groups that can form hydrogen bonds
with water molecules.
4.
The major noncovalent interactions that determine the structure and function of biomolecules are
electrostatic interactions and hydrophobic interactions.
2.
Electrostatic interactions include charge-charge interactions, hydrogen bonds, and van der
Waals forces.
Hydrophobic interactions: dissociation energy depends on the increased entropy of surrounding
water molecules rather than on direct attraction between nonpolar groups.
3.
Under cellular conditions, macromolecules do not spontaneously hydrolyze, despite the presence of
high concentration of water.
Specific enzymes catalyze their hydrolysis and other enzymes catalyze their energy-requiring
synthesis.
4.
van der Waals forces (London dispersion force) are much weaker than hydrogen bonds (0.4 to
4kJ/mol versus 2 to 20 kJ/mol)
5.
Covalent bond has dissociation energy of approximately 340 450 kJ/mol (C-H or C-C)
If you like biochemistry, you must know the chemistry in that word. And acid/base is
the utmost importance.
Prelude
At 25oC, [H+][OH-] has a value of 1.0 x 10-14 M2 = Kw the ion-product constant for water
(This means pure water ionizes to produce 10-7 M of H+ and 10-7 M of OH- )
The acidity and basicity of an aqueous solution depends on the concentration of H + and is
described by a pH value.
The strength of a weak acid is indicated by its pKa value. The Henderson- Hasselbalch
equation defines the pH of a solution of weak acid in terms of the pKa and the
concentration of the weak acid and its conjugate base.
DGD wednesdays
eyy074@uottawa??
Memorizing aas
Part 1: https://www.youtube.com/watch?v=gq-rWb0fmzQ
Part 2: https://www.youtube.com/watch?v=C2GfoGXfySQ
Know pkas
Kd will be high