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(ALDO INCREASES
EC FLUID VOLUME)
( physioweb.med.uvm.edu)
CORTISOL
Glukokortikoid
Biosintesis kortisol
ACTH
ACTH +R mengaktifkan adenil
siklase AMP intrasel
mengaktifkan protein kinase A
fosforilasi kolestril ester hidrolase
menjadi kolesterol bebas
Efek Glukokortikoid
Efek fisiologik
Efek Farmakologik
$ Efek Metabolik
- Glukoneogenesis
- proteolisis
- lipolisis
$ Efek Permisif
$ Efek antiinflamasi
(Fisiologi
ganong,,,Fisiologi
sheerwood)
Glukokortikoid
Efek:
Merangsag glukoneogenesis hati
kadar glukosa darah
Menghambat penyerapan &
penggunaan glukosa olh bnyk jar, kec
otak
Merangsang penguraian protein
lipolisis di jar adiposa as lemak
darah
jmlh eosinofil dlm darah dg
sekuestrasinya di limpa & paru
Mekanisme kerja:
Glukokortikoid + R transkripsi DNA
translasi mRNA sintesis enzim yg
menubah fungsi sel
CORTISOL AND
FOODSTUFF METABOLISM
Physioweb.med.uv
m.edu
Spesific Target
Physiologic
Function
S. Imun
Monosit
Menghambat
proliferasi
Skin n
Connective
Tissue
Cardivascular
Antiproliferatif
for fibroblast
Heart
Increased
Contractility
(Basic n Clinical
endrocrinology
CORTISOL
EFFECTS OF DEFICIT.
1. Cells/Organs/Systems cannot respond to external signals/stresses.
Examples: cardiovascular system cannot respond to exercise; kidney
cannot respond to a water load or dehydration; liver cannot respond to
epinephrine. Any major stress to the body can lead to death.
EFFECTS OF EXCESS.
1. Suppression of Immune and inflammatory reactions.
2. Breakdown of Connective Tissue and Bone.
3. Metabolism (see below): increased incidence of Diabetes Mellitus.
4. Excess can have mineralocorticoid effects on electrolytes (due to
structural similarities between cortisol and aldosterone).
EFFECTS ON FOODSTUFF METABOLISM.
Carbohydrate
Increased gluconeogenesis from protein
Reduced glucose uptake by muscle
Increased appetite
Fat
Peripheral mobilizatoion
Central (axial) deposition
(Buffalo Hump)
Increased appetite: body weight/
Fat increases
Protein
Increased muscle protein breakdown: muscle wasting
Increased synthesis of liver gluconeogenic enzymes
(e.g. transaminases)
Overall
Unmasking of Diabetes Mellitus
www.medicalstu
dent.com
Pengaturan sekresi
Glukokortikoid
Stress
Irama diurnal
(-) Hipotalamus
(CRH)
(-) H. Anterior
(ACTH)
Glukosa drh
As.amino drh
Korteks Adrenal
Kortisol
As.lmk drh
Fisiologi Sheerwood
www.medicalstudent.c
om
Physioweb.med.uvm.e