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HUMAN PHYSIOLOGY
AN INTEGRATED APPROACH
Dee Unglaub Silverthorn, Ph.D.
Chapter 24
The Immune System
Life Cycle
Lymphatic System:
Overview of Immune Defense Organs & Cells
Bone marrow
Thymus
Lymph nodes
Spleen
Lymph vessels
Leukocytes:
(white blood cells WBCs)
Lymphatic System:
Overview of Immune Defense Organs & Cells
Histamine
Bradykinin
Serotonin
Leukotrienes
Prostaglandins
B Cell Activation
Tapasin
CR
CN
DM
monitors
peptide
specificity
for DR
DM
Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Binds 13-25mers
Expressed on APCs,
Macs, B cells, activated
T cells
Presents Vesicular
Proteins to CD4+ T cells
2 3
Class I
Class II
BDC
Endocytosis
+
CD4
CD4+
TT cell
cell
APC
TCell
Receptor
Peptide
MHCII
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Humoral
Versus
Cellular
Immune
Response
Complement
& cytokines
Gene
Allele:
Haplotype:
Genotype:
HLADRB1*0401
HLADRB1*0401
HLADQB1*0302
HLADRB1*0301
HLADQB1*0201
DRB1*02
HLADRB1*04
HLADQB1*0302
J. Noble
Antigen Presentation
Viral Defense:
Summary of Innate & Acquired Responses
Viral Defense:
Summary of Innate & Acquired Responses
Allergic Response:
Inflammation Reaction to Non-pathogen
First exposure: sensitization
Activation
Clone B cells
Form antibodies
Memory cells
Re-exposure
Many antibodies
Activated Ts
Intensified
Inflammation
Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Allergic Response:
Inflammation Reaction to Non-pathogen
Blood Types:
Like Antibodies & antigens will agglutinate
Blood Types:
Like Antibodies & antigens will agglutinate
Figure 24-21: Model for interaction between nervous, endocrine, and immune systems
Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings
Summary
Summary