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We Are:
Surya P Kannan
Monu Varghese
Flora Philip
Bijily Thomas
Vincy Francis
Blessy Thomas
Elma Simon
Vanita Sharon
I.V.F.
In
Vitro
Fertilization
Test tube babies
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IVF
In vitrofertilisation (IVF) is a process by
which an egg is fertilised by sperm outside
the body: in vitro. IVF is a major treatment
for
infertility when
other
methods
of assisted reproductive technology have
failed.
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Let us Review
Femalereproductivesystem
Malereproductivesystem
NormalFertilization
IVF: In vitro
fertilization
In vitro: in glass
Basic Principle of
Hormonal
treatment
Female
Harvest
theovum
MatureOva
Mixinatesttube
Motilesperms
Keepto
develop
embryo
Collectsemen
Natural
ejaculation
Male
Transfer
tomother
Hormonal Treatmen
Drugscurrentlyinuseinclude:
clomiphenecitrate(Clomid,Serophene)
humanmenopausalgonadotropin(hCG)
gonodotropinreleasinghormone(GnRH)analogcalled
leuprolide(Lupron)
Mostofthesedrugsmaybeusedaloneorina
combinationwithothers.
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Egg Harvest
1. UltraSoundGuidedAspiration
2. Laproscopy
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Oocyteswith
granulosacells
"Naked"Oocyte
8-cellembryofortransfer
Blastocystfortransfer
Implantation
FourteenDaysafterInitialCellDivision
ViableFetus
AfterBirth
Alternates of IVF
Gamete intrafallopian transfer (GIFT): GIFT
is similar to IVF. It is used when a woman has at
least one normal fallopian tube. Eggs are placed in
this tube along with a mans sperm to fertilize there.
Zygote intrafallopian transfer (ZIFT): ZIFT is tubal
embryo transfer in which a womans eggs are taken
from her ovaries, fertilized in the laboratory, and put
back in the fallopian tubes rather than the uterus.
Alternates of IVF
Assisted fertilization techniques when not enough
sperm are available or sperm quality is not
sufficient to fertilize include the following:
Alternates of IVF
ICSI
Standsforintracytoplasmicsperminjection.This
processisusedtoinjectasinglespermintoeachegg
beforethefertilizedeggsareputbackintothewoman's
body.Theproceduremaybeusedifthemalehasalow
spermcount.
Alternates of IVF
CryopreservationofOva,SpermandEmbryo
Risks
SuperovulationStimulatesEggDevelopment
OvarianHyperstimulationSyndrome(OHSS)
Normalresults
Success rates vary widely between clinics and between
physicians performing the procedure and implantation does
not guarantee pregnancy. Therefore, the procedure may
have to be repeated more than once to achieve pregnancy.
However, success rates have improved in recent years, up
from 20% in 1995 to 27% in 2001.
Abnormalresults
An ectopic or multiple pregnancy may abort spontaneously
or may require termination if the health of the mother is at
risk. The number of multiple pregnancies has decreased in
recent years as technical advances and professional
guidelines have led to implanting of fewer embryos per
attempt.
Ethics
Bypassingthenaturalmethodof
conception.
Thecreationoflifeinthelaboratory.
Fertilizationofmoreembryosthanwillbe
needed.
Discardingofexcessembryos.
Unnaturalenvironmentforembryos.
Useofuntestedtechnology.
Ethics
Notaffordableformany.
Misallocationofmedicalresources.
Creationofembryos,thenfreezingthem,and
keepingthem"inlimbo".
Exposureofembryostounnaturalsubstances.
Destructionofembryosinresearch.
Potentialtocreateembryosformedical
purposes.
Potentialtoselectembryos(PGD).
Ethics
Potentialtomodifyembryos.
Facilitationoftheideathatembryosare
commodities.
FinancialrewardsforIVFdoctorsdissuade
themfromrecommendingothermethodsto
couples.
Infertilityistreatedasadiseaseandnotasa
symptomofunderlying
medicalproblems.
Ethics
Separatingthetraditionalmother-father
model
Pregnancypastmenopause
Religious objections
3.Thechildmustbeagiftnotaproduct
Thechildhastherighttobethefruitof
thespecificactoftheconjugalloveofhis
parents.
Product
Genetic testing
A kind of quality control selection
Where is it going?
To create the perfect baby disease free,
blond hair, blue eyed, good footie player
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You formed
my inmost being;
you knit me in my
mother's womb.
Fearfully and
wonderfully
made!
Psalm 139
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Thank you