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MED 1103
HEMATOPOIESIS
Location
Prenatal
1.
2.
3.
4.
Postnatal
1. exclusively in bone marrow
2. in disease states, spleen and
liver can produce blood cells
Bone Marrow
1. structure: reticular fibers, veins, arteries,
sinusoids, islands of cells
2. red marrow: active hematopoiesis
3. yellow marrow: fat in reticular cells,
inactive hematopoiesis
Production
1. greater than 109 (billion) cells produced daily
2. stem cells pleuripotent, low numbers, give rise to:
3. multipotential cells
a. colony forming units spleen (myeloid cell lines)
b. colony forming units lymphocytes (lymphoid cell lines)
4. progenitor cells committed to a single cell line, limited self renewal
5. precursor cells morphologically distinct, no self renewal
a. generally referred to as a "_____blast" which differentiates
to a "____cyte"
b. as cells develop; decrease in size, nuclei condense
MHSC
Prelymphocytes
CFU-LyB
CFU-Ly
Ly
m
ph
op
oi
es
is
CFU-LyT
CFU-Meg
PHSC
MKB
MKC
CFU-M
Promonocyte
CFU-N
Myeloblast
CFU-Ba
CFU-Ba
Myeloblast
CFU-Eo
CFU-Eo
Myeloblast
CFU-NM
My
e lo
po
is
ie s
CFU-GEMM
Myeloid stem cell
BFU-E
Stem Cells%
CFU-E
Progenitor Cells%
Proerythroblast
Precursor Cells%
Regulation
1. hematopoietic growth factors (colony stimulating factors)
glycoproteins
2. interleukins, granulocyte colony stimulating factor, erythropoietin, etc.
3. stem cell factor (steel factor) stromal cells of the bone marrow,
stimulates division
4. hematopoietic cells will die unless exposed to growth factors
ERYTHROPOIESIS
GRANULOCYTOPOIESIS