Take out your protein

functions homework.
 SBI4U

Enzymes
Amoeba Sisters Video
https://www.youtube.com/watch?v
=qgVFkRn8f10&list=PLwL0Myd7Dk1F0iQPGrjehze3eD
pco1eVz&index=4
Demos
Puzzle Piece Activity

Find the partner to your puzzle piece

E must react with S

Once you find your partner wave your

hands in the air
 Enzymes
Proteins that have a very specific, unique shape

Has a groove on the surface called an active site

Allows them to meet up with a substrate that fits perfectly

There are specific enzymes for specific

reactions
Proteases breakdown proteins
Lipases breakdown lipids
DNA polymerase builds DNA
HINT: Most enzyme
names end with the
Enzyme Vocabulary
Enzyme
o The helper protein molecule

Substrate
o The molecule that enzymes work on

Products
o What the enzyme helps produce from the reaction

Active site
o Part of the enzyme that substrate molecule fits into
 +
Enzyme Substrate Enzyme-
Substrate
Complex
 Product

Enzyme-
Enzyme
Substrate
Complex
Enzymes
Not used up in the reactions they
assist
They are Catalysts

Q: What is a catalyst?/What do
they do?
Catalysts
Speed up chemical reactions

Without them, reactions would happen SLOWLY

Catalysts
Speed up chemical reactions
Without them, reactions would
happen SLOWLY
They do this by lowering the
activation energy of the reaction
Factors that Influence
Enzyme Activity
Temperature

pH

Inhibitors
 Temperature and pH
Temperatures above normal range
denature enzymes
Without their shape, they cannot
properly bind to the substrate

Most enzymes work best near neutral

pH (6 to 8)
Come trade in your puzzle
pieces!
 Find your partner!

ONLY E + S will result in a

reaction!
E + I will not!
Hands up if you are have no
partner!

Keep hands up if you are a

substrate!
What was different than the
first time??

Why werent all the

substrates paired?
If you have a piece with an I,
come trade in
Find your partner!
How many substrates have
no partner?

How many I pieces?

What happened this time?
Competitive Inhibition
Competitive Inhibitor:
resembles the substrate and
competes with the substrate
for the active site of the
enzyme
Can be reversed depending
on the concentration of
inhibitor and substrate
Increase substrate
concentration and competitive
inhibition will decrease
Come trade in your puzzle
pieces!

What do you think will

happen this time?
 Find your partner!

If you are an I, give the

modified E to your partner to
use instead!
How many substrates have
no partner?
Non-Competitive Inhibition
Non- Competitive
Inhibitor: Binds a site on the
enzyme other than the active
site changing the shape of
the active site
Can be reversed depending
on the concentration of
inhibitor and substrate
Decrease substrate
concentration and competitive
inhibition will decrease
Homework!
Write an analogy about enzymes and their substrates

Include true scientific facts in your analogy

If you need more information include some

researched topics in your analogy
Be CREATIVE!

May be written or drawn as a comic!

Due in two days!