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PALOMO
RICO
SALOMA
SILOMENIO
VICENTE
History
- due to their extremely small
size, parvoviruses were only
recently discovered
Dependoviruses
~ the first parvoviruses to be
discovered, were first isolated
in the 1960s
Parvovirus B19
1. B19 &
Adenoassociated Virus
2. Canine Parvovirus
Type 2
3. Feline Panleukopenia
4. Porcine Virus
5. Kilham Rat Virus
Morpho-anatomy
CAPSID: Icosahedral symmetry
made with 2-4 VP1-proteins.
Naked viruses with a shape thats
roughly spherical, with surface
protrusions and canyons.
Genome
-ssDNA of about 4-6kb
-Each end: short complementary
sequences that can base pair to form a
secondary structure
2. Role of antibodies
Interestingly, antibodies may serve two roles in B19
infections. While neutralizing antibodies help patients
clear the virus in both acute and persist infections,
Laboratory Diagnosis
FETAL
SPLEEN
Treatment
&
Control
Parvovi
DEFECTIVE
ruses
IMMUNITY
Introduction (Types of immune defect)
Congenital, or primary
Acquired, or secondary
Primary Immunodeficiencies