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Claviceps purpurea/Hypocreaceae
in China: 3 scleroti/nastere
derivai levo - IN
dextro - ININ
7 HOOC CH3
8 6N N
9 D5 H
10 4
C 3
11
12 16 2
13 A B
NH NH
14
N
H
2. Alcaloizi polipeptidici
R R
CH OH
- 80% din totalul alcaloidic O
CO-NH N
H3C N
- ergopeptine N
O O
R1
R, R R1
ergotamina H, H - CH2-C6H5
OH L-prolina
O
CO-NH N
H3C N
N
O O
CH2
fenilalanina
C6H5
hidroxialanin
a
3. Alcaloizi clavinici
CH2OH CH2OH
H3C NH H3C N H 3C N
N N N
H H H
bruni: melanine
OH
CH3 O
N
O N N H
H O
H
O H
R
N
CH3
H
HN
ergotamina
Aciune
1. datorit 9,10 aciune ocitocic: alcaloizi de tip
aminoalcool
H R R
H 3C N *
COOH CH OH
O
CO-NH N
H3C N
N
O O
N
H R1
- antihemoragic uterin,
- se administreaz i p.o.,
DH-ergotamina
- doze terapeutice: vasoconstrictor
- nu mai prezint activitate ocitocic
- antimigrenos (spray nazal)
- sindrom ortostatic
Ergotamina
- reduce fluxul sanguin extracranian
- scade amplitudinea pulsatiilor in arterele
craniene
- distonii neuro-vegetative
Derivai semisintetici/sintetici
Metilergometrina
- Sermion
2-brom-ergocriptina
- inhib secreia de prolactin de ctre hipotalamus
- antiparkinsonian: agonist dopaminergic
- hipotensiv
- dozele mari = emetic
- inhibarea lactaiei post-partum, tulburri benigne
ale snului
- boala Parkinson
- Parlodel, Bromocriptin
dedublarea personalitii
simpatomimetic
provoac toleranta
- instabilitate emoional
(alternan de bucurie, fric,
anxietate, furie, fericire, iritare)
- anxietate, paranoia, fric i panic;
- tensiune, contractarea maxilarului, transpiraie abundent;
Compoziie chimic
lisergamida (2-10 mg halucinogen); chano-, elimo-, agroclavina
fitosteroli, aminoacizi, saponozide