Multiple choice questions

Mycobacterium tuberculosis
The scientist who discovered M.
tuberculosis was:
A: Louis Pasteur
B: Robert Koch
C: Jean-Antoine Villemin
D: Calmette and Guerin

Correct answer: B
MDR TB: is defined as resistance to
A: more than three anti tubercular drugs
B: isoniazid and rifampin irrespective of
resistance to any other drug
C: INH, PZA and Rifampicin
D: fluoroquinolones and at least one of the
three injectable second-line drugs used to
treat TB

Correct answer: B
XDR TB is defined as
A: MDR TB that also is resistant to fluoroquinolones and at
least one of the three injectable second-line drugs used to
treat TB (amikacin, kanamycin, or capreomycin)
B: resistant to two most effective first-line therapeutic drugs,
isoniazid and rifampin irrespective of resistance to any other
drug
C: MDR TB that is resistant to either one of the injectable
second line drugs or second-line therapeutic fluoroquinolones
D: Strain resistant to more than one drug (excluding co
resistance to INH and rif)

Correct answer: A
Tuberculosis is transmitted through:
A: Infected water
B: Infected hands
C: Infected blood
D: Infected air

Correct answer: D
Which of the following statements is incorrect:
A: People who are exposed to TB may or may not
develop TB infection
B: People with TB infection may or may not develop
TB disease
C: risk of developing TB disease is highest in first 2
years after infection
D: Every individual exposed to TB develops disease

Correct answer: D
 Tubercular Granulomas are made up
of:
A: organized aggregates of immune cells
that surround foci of infected tissues
B: Damaged tissue cells and bacilli only
C: Fibrous and damaged tissue and bacilli
only
D: Necrotic tissue and damaged tissue
and bacilli only

Correct answer: A
 Cord growth seen on mycobacterial
culture is characteristic of:
A. Avirulent strains
B. Virulent strains
C. Saprophytic strains
D. Atypical mycobacteria

Correct answer: B
 Which one of the following are
constituent of Lowenstein Jensen
media except:
A. Agarose
B.Malachite gree
C. Mineral salts
D. Asparagine

Correct answer: A
 Following are the first line
antitubercular drugs except:
A. isoniazid
B. rifampin
C. PAS
D. streptomycin

Correct answer: C
 Which one of the following anti-
tubercular drugs acts best in acidic
pH:
A. INH
B. Pyrazinamide
C. Streptomycin
D. Rifampicin

Correct answer: B
 Mutations in katG gene of
Mycobacterium tuberculosis are
responsible for resistance to:
A. INH
B. Rifampicin
C. Pyrazinamide
D. Streptomycin

Correct Answer: A
 Which of the following tests are
banned for diagnosis of tuberculosis:
A. Culture
B. ELISA
C. PCR
D. LPA

Correct result: B
 Which of the following statements is
incorrect:
A. Mycobacteria are obligate aerobes
B. Increased CO2 tension enhances growth
C. Can not grow in cell free media
D. Doubling time of tubercle bacilli is
about 18 hours.

Correct answer: C
One word answer
Identify the stain
ZN stain
Identify the
organism
M. tuberculosis
Describe the
morphology
Acid fast, Long
slender, curved,
bunch, beaded
 True/ False
For people with TB infection and no risk factors, the risk is
about 5% in the first two years
T
For people with TB infection and no risk factors, the risk is
about 10% over a lifetime
T
For people with TB infection and diabetes, the risk is about 30%
over a lifetime
T
For people with TB infection and HIV infection , the risk is
about 7% to 10% over a lifetime
F
 Which one of the following is a non
cultivable mycobacteria:
A. M. tuberculosis
B. M. Bovis
C. M. leprae
D. M. avium intracellulare

Correct Answer: C
 Which one of the following is a rapid
grower mycobacteria:
A. M. scrofulaceum
B. M. kansasii
C. M. fortuitum
D. M. avium intracellulare

Correct Answer: C
 Buruli ulcer is caused by:
A. M. tuberculosis
B. M. ulcerance
C. M. marinum
D. M. chelonei

Correct answer: B
 Swimming pool granuloma is caused
by:
A. M. tuberculosis
B. M. ulcerance
C. M. marinum
D. M. chelonei

Correct answer: c
 Most common cause of disseminated
opportunistic infection in AIDS patients
in western world is:
A. M. avium intracellulare complex
B. Pneumocystis carinii
C. Cryptosporidium
D. Zygomycetes

Correct answer: A
 Gerhard Henrik Armauer Hansen,s contribution
to Microbiology was;
A. First identified M. leprae as the cause of leprosy in
1873
B. First identified M. tuberculosis as a cause of TB in
1895
C. First identified B. anthracis as a cause of Anthrax in
1872
D. First identified that small pox is a contagious disease

Correct Answer: A
 Which of the following description suits lepra bacilli best:
A. acid-fast rod-shaped organism with parallel sides and rounded
ends, mostly extracellular, often grouped together like bundles
of cigars
B. acid-fast rod-shaped organism with parallel sides and rounded
ends, chiefly in masses within the lepra cells (globi), often
grouped together like bundles of cigars or arranged in a palisade
C. acid-fast rod-shaped organism with parallel sides and rounded
ends, chiefly intracellular in Chinese letter form
D. acid-fast rod-shaped organism, extracellular, Chinese letter
form

Correct answer: B
 An adult male is presenting with hypo-
pigmented patches on forearm, partial loss of
cutaneous sensations in affected areas,
presence of thickened ulnar nerve and presence
of AFB in nasal smears. Your diagnosis is:
A. Cutaneous Tuberculosis
B. Leprosy
C. Atypical mycobacteriosis
D. Actinomycosis

Correct answer: B
 A case of leprosy with good Cell
mediated immunity usually presents
as following form of disease:
A. Lepromatous
B. Tuberculoid
C. indeterminate
D. Borderline

Correct answer: B
 Erythma nodosum leprosum as seen
in patients of leprosy on treatment, is
due to:
A. Type I hypersensitivity reaction
B. Type II hypersensitivity reaction
C. Type III hypersensitivity reaction
D. Type IV hypersensitivity reaction

Correct answer: C
 Presence of sulfur granules in pus is
pathognomonic of:
A. Subcutaneous mycosis
B. Leprosy
C. Actinomycosis
D. Cutaneous Tuberculosis

Correct Answer: C
 There is a 30 year old male presenting with
lumpy jaw, suppurative inflammation and
formation of multiple abscesses and sinus
tracts with discharge of pus containing sulfur
granules. Most probable clinical diagnosis is;
A. Leprosy
B. Actinomycosis
C. Subcutaneous mycosis
D. Cutaneous TB

Correct Answer: B
 There is a 30 year old male presenting with lumpy
jaw, suppurative inflammation and formation of
multiple abscesses and sinus tracts with discharge
of pus containing sulfur granules. Following types of
microscpic examinations can be ordered to confirm
the diagnosis, except;
A. Smear examination for Gram positive bacteria
B. Microscopic examination of Crush smear of granule
C. Smear examination for acid fast bacilli
D. KOH mount

Correct answer: D
 There is a 30 year old male presenting with
lumpy jaw, suppurative inflammation and
formation of multiple abscesses and sinus
tracts with discharge of pus containing sulfur
granules. Best therapy in this case will be:
A. Antitubercular drugs
B. Aminoglycosides
C. Penicillin
D. Co trimoxazole

Correct Answer: C
 Which one of them is non acid fast:
A. Mycobacterium tuberculosis
B. Nocardia
C. Actinomyces
D. Mycobacterium leprosy

Correct Answer: C