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James L,

Atoms and Molecules:


General Biology I (MF009) The Chemical Basis of
Foundation in Science
Powerpoint Templates Life Page 1
Learning Objectives
To define matter

To explain the different states, properties and


classification of matter

To understand the concept of chemical bonds

To distinguish among covalent bonds, ionic bonds,


hydrogen bonds, and van der Waals interactions

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Chemistry and Life
All organisms share fundamental similarities in their
chemical composition and basic metabolic
processes

The structure of atoms determines the way they form


chemical bonds to produce complex compounds

Molecular biology
Molecular biology is the study of biology at a
molecular level.

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BASIC CHEMISTRY OF A CELL
The living cell is a symphony of thousands of chemical
reactions all miraculously timed and coordinated to perform all
the functions necessary for life.

Biology includes the study of molecular and atomic nature of


life and living systems - some basic understandings in
chemistry is required in order to fully understand important
ideas in biology.

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BASIC CHEMISTRY OF A CELL
All the structures of the body are composed of chemicals,
and all the functions of the body result from the
interactions of these chemicals with one another.

The generation of nerve impulses and


the physiologic processes of digestion,
muscle contraction, and metabolism
can be described in chemical terms.

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Matter
Matter
Anything that has mass and takes up space
All organisms and everything around them are made of
matter.
All matter is composed of atoms & elements.
Understanding the structure of atoms is critical to
understanding the nature of biological molecules.
Why do we need to classify matter?
not all matter is the same
different types of matter must be treated
differently

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ELEMENTS
ELEMENTS
Substances that cant be broken down into simpler substances by
ordinary chemical reactions

Each element has a chemical symbol (Example: C for carbon)

Four elements (oxygen, carbon, hydrogen, and nitrogen)


make up more than 96% of the mass of most organisms

Calcium, phosphorus, potassium, and magnesium, are present in


smaller quantities

Trace element Dietary


Iodine and copper are trace elements element that is needed in
minute amount.
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Human : What are we made of?

Chemical composition of the human body by weight


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Atoms
Smallest unit of an element that retains that elements
chemical properties

Made up of tiny subatomic particles of matter

All matter is composed of atoms.

Understanding the structure of atoms is critical to


understand the nature of biological molecules.

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Subatomic Particles
There are three basic types of subatomic particles:
An electron carries a unit of negative electric charge
A proton carries a unit of positive charge
A neutron is an uncharged particle

Protons and neutrons are compose in the atomic


nucleus
Electrons move rapidly around the atomic nucleus
In an electrically neutral atom, the number of
electrons equals the number of protons

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Atomic Structure
Every different atom has a characteristic number of protons in the
nucleus.

Every element has a fixed number of protons in the atomic nucleus


(atomic number), which determines an atoms identity and defines
the element.
Ions are charged atoms.
cations have more protons than electrons and are
positively charged
anions have more electrons than protons and are
negatively charged

The periodic table is a chart of the elements


arranged in order by atomic number and chemical
behavior
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All of the Elements are arranged on a chart known
as the Periodic Table

Electron-shell diagramsPowerpoint
of the firstTemplates
18 elements in the periodic table.
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Atomic number & Mass number
Atomic number
Number of protons in the nucleus of an atom
Equals with the number of electrons in the atom
Each element has a unique atomic number

Mass number
The number of protons plus(+) number of neutrons
in one atom
expressed in atomic mass unit (amu) or
daltons
Electrons do not contribute to the weight of
an atom
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Isotopes
Most elements consist of a mixture of atoms with different
numbers of neutrons and different masses
Isotopes
Atoms of the same element (having the same number of
protons and electrons) with varying numbers of neutrons

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Radioisotope
Some isotopes are unstable and tend to break down (decay)
to a more stable isotope (usually a different element)

Radioisotope
Unstable isotope that emits radiation as it decays. Radioactive
decay can be detected by autoradiography, on photographic
film
Example: Radioisotopes such as 3H (tritium), 14C, and 32P can
replace normal molecules and are used as tracers in research

In medicine, radioisotopes are used for both diagnosis


(such as thyroid function or blood flow) and treatment
(such as cancer)

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Compounds and Molecules
Two or more atoms may combine chemically

A chemical compound consists of atoms of two or more different


elements combined in a fixed ratio

Two or more atoms joined very strongly form a stable molecule

Example: H20 (water) is a molecular compound

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Inorganic and Organic Compounds

Inorganic compounds Organic compounds

Small, simple substances Generally large, complex carbon-


containing compounds
Biologically important groups
include water, simple acids and Typically, two or more carbon
bases, and simple salts atoms are bonded to each other
to form the backbone, or
skeleton, of the molecule

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Chemical Bonds
Atoms can be held together by chemical bonds

Valence electrons dictate how many bonds an atom can


form

Bond energy
Energy necessary to break a chemical bond

Two types of strong chemical bonds: covalent and ionic

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Covalent Bonds
Covalent bonds involve sharing electrons between atoms in a way
that fills each atoms valence shell

A molecule consists of atoms joined by covalent bonds


Example: hydrogen gas (H2)

Atoms linked by covalent bonds form a covalent compound


Carbon has 4 electrons in its valence shell, all of which are
available for covalent bonding (e.g. methane, CH4)

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Single, Double, and Triple Covalent Bonds

When one pair of electrons is shared between two atoms, the


covalent bond is called a single covalent bond

A double covalent bond is formed when two pairs of electrons


are shared (represented by two parallel solid lines)

A triple covalent bond is formed when three pairs of electrons


are shared (represented by three parallel solid lines)

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Covalent Bonds

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Covalent Bonds
Covalent bonds form when atoms share 2 or more
valence electrons.

Covalent bond strength depends on the number of


electron pairs shared by the atoms.

single double triple


bond < bond < bond

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Bonds found in biologically important
molecules

Atom Symbol Covalent Bonds


Hydrogen H 1
Oxygen O 2
Carbon C 4
Nitrogen N 3
Phosphorus P 5
Sulfur S 2

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Polar and Nonpolar Covalent Bonds

Electronegativity
A measure of an atoms attraction for shared electrons in
chemical bonds (e.g. oxygen has high electronegativity)

Nonpolar covalent bond


When covalently bonded atoms have similar electronegativities,
electrons are shared equally

Polar covalent bond


Covalent bond between atoms that differ in
electronegativity; electrons are pulled closer to the
nucleus of the atom with greater electron affinity

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Polar Molecules
A polar covalent bond has two dissimilar ends (poles), one
with a partial positive charge and the other partially negative

A polar molecule has one end with a partial positive charge


and another end with a partial negative charge

Example: Water has a partial positive charge at the hydrogen


end and a partial negative charge at the oxygen end, where
shared electrons are more likely to be

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Ionic Bonds
An ionic bond is formed by attraction between the
positive charge of a cation and the negative charge of an
anion

An ionic compound is a substance consisting of anions


and cations bonded by their opposite charges

Example: Sodium chloride (NaCl), an ionic compound


When sodium reacts with chlorine, sodiums single valence
electron is transferred completely to chlorine
Sodium becomes a cation (Na+); chlorine becomes an anion
(Cl)

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Ionic Bonds
Ionic bonds are formed by the attraction of oppositely
charged ions.

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Ionic Compounds in Solution

In the absence of water, ionic bonds are very strong


Example: Electrical attraction in ionic bonds holds Na+ and Cl
together to form NaCl (sodium chloride, table salt)

When placed in water, ionic compounds (such as sodium


chloride) tend to dissociate into individual ions :

NaCl (in H2O) Na+ + Cl

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Water as a Solvent
Water is an excellent solvent, capable of dissolving
many substances (solutes)

Because of their polarity, water molecules easily dissolve


polar or ionic substances

In solution, each cation or anion is surrounded by


oppositely charged ends of the water molecules
(hydration)

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Hydrogen Bonds
Hydrogen bonds are relatively weak bonds (easily formed and
broken) that are very important in living organisms

When hydrogen combines with a relatively electronegative atom,


it acquires a partial positive charge

Hydrogen bonds form between an atom with a partial negative


charge and a hydrogen atom that is covalently bonded to oxygen
, nitrogen, or fluorine

Water molecules interact with one another extensively


through hydrogen bond formation

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Hydrogen Bonds

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Van der Waals interactions
Adjacent molecules may interact in transient regions of weak positive
and negative charge. Van der Waals forces are electrostatic in nature.

The resulting attractive forces (van der Waals interactions) operate


over very short distances and are weaker and less specific than other
types of interactions

If the atoms are far apart (a few atomic radius away) from each other,
the van der Waals force becomes insignificant.

They are important when they occur in large numbers and


when molecular shapes permit close contact between
atoms

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Chemical Bonds
Chemical reactions involve the formation or breaking of chemical bonds.

A chemical reaction occurs is influenced by:


- temperature
- concentration of reactants and products
- availability of a catalyst

Chemical reactions are written with the reactants first, followed by


the products.

6H2O + 6CO2 C6H12O6 + 6O2


reactants products

Chemical reactions are often reversible.


C6H12O6 + 6O2 6H2O + 6CO2
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