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Chemistry and Life
All organisms share fundamental similarities in their
chemical composition and basic metabolic
processes
Molecular biology
Molecular biology is the study of biology at a
molecular level.
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BASIC CHEMISTRY OF A CELL
The living cell is a symphony of thousands of chemical
reactions all miraculously timed and coordinated to perform all
the functions necessary for life.
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BASIC CHEMISTRY OF A CELL
All the structures of the body are composed of chemicals,
and all the functions of the body result from the
interactions of these chemicals with one another.
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Matter
Matter
Anything that has mass and takes up space
All organisms and everything around them are made of
matter.
All matter is composed of atoms & elements.
Understanding the structure of atoms is critical to
understanding the nature of biological molecules.
Why do we need to classify matter?
not all matter is the same
different types of matter must be treated
differently
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ELEMENTS
ELEMENTS
Substances that cant be broken down into simpler substances by
ordinary chemical reactions
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Subatomic Particles
There are three basic types of subatomic particles:
An electron carries a unit of negative electric charge
A proton carries a unit of positive charge
A neutron is an uncharged particle
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Atomic Structure
Every different atom has a characteristic number of protons in the
nucleus.
Electron-shell diagramsPowerpoint
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18 elements in the periodic table.
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Atomic number & Mass number
Atomic number
Number of protons in the nucleus of an atom
Equals with the number of electrons in the atom
Each element has a unique atomic number
Mass number
The number of protons plus(+) number of neutrons
in one atom
expressed in atomic mass unit (amu) or
daltons
Electrons do not contribute to the weight of
an atom
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Isotopes
Most elements consist of a mixture of atoms with different
numbers of neutrons and different masses
Isotopes
Atoms of the same element (having the same number of
protons and electrons) with varying numbers of neutrons
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Radioisotope
Some isotopes are unstable and tend to break down (decay)
to a more stable isotope (usually a different element)
Radioisotope
Unstable isotope that emits radiation as it decays. Radioactive
decay can be detected by autoradiography, on photographic
film
Example: Radioisotopes such as 3H (tritium), 14C, and 32P can
replace normal molecules and are used as tracers in research
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Compounds and Molecules
Two or more atoms may combine chemically
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Inorganic and Organic Compounds
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Chemical Bonds
Atoms can be held together by chemical bonds
Bond energy
Energy necessary to break a chemical bond
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Covalent Bonds
Covalent bonds involve sharing electrons between atoms in a way
that fills each atoms valence shell
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Single, Double, and Triple Covalent Bonds
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Covalent Bonds
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Covalent Bonds
Covalent bonds form when atoms share 2 or more
valence electrons.
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Bonds found in biologically important
molecules
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Polar and Nonpolar Covalent Bonds
Electronegativity
A measure of an atoms attraction for shared electrons in
chemical bonds (e.g. oxygen has high electronegativity)
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Polar Molecules
A polar covalent bond has two dissimilar ends (poles), one
with a partial positive charge and the other partially negative
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Ionic Bonds
An ionic bond is formed by attraction between the
positive charge of a cation and the negative charge of an
anion
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Ionic Bonds
Ionic bonds are formed by the attraction of oppositely
charged ions.
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Ionic Compounds in Solution
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Water as a Solvent
Water is an excellent solvent, capable of dissolving
many substances (solutes)
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Hydrogen Bonds
Hydrogen bonds are relatively weak bonds (easily formed and
broken) that are very important in living organisms
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Hydrogen Bonds
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Van der Waals interactions
Adjacent molecules may interact in transient regions of weak positive
and negative charge. Van der Waals forces are electrostatic in nature.
If the atoms are far apart (a few atomic radius away) from each other,
the van der Waals force becomes insignificant.
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Chemical Bonds
Chemical reactions involve the formation or breaking of chemical bonds.