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FETAL
GROWTH
placental maternal
Introduction
Inheritance
Growth
potential
HEALTHY NEWBORN
FETUS Normal circumstances & APPR- SIZE
Introduction
Growth Environ-
potential ment
Ability to
reach optimal
birth weight
Accelerating Maximum Decelerating
Slow Growth
Growth Growth Growth
The normal rate of fetal growth in an ideal cases is limited by its internal constraints
(genetic in nature)
Introduction
Amino
Acids
Glucose
Oxygen
Fetal requirement
Simple Diffusion
Facilitated Diffusion
Active Transport
Persistent decrease in availability of any of
these substrates limit the ability of the
fetus to reach its growth potential
Persistent and severe substrate deficiency
threaten the ability of the fetus to survive
So many factors associated with reducing
substrates supplies to the fetus
Intrauterine Growth Intrauterine Growth
Retardation Restriction
SGA : 37 %
IUGR: 3 quarter (failed to achieve its potential
growth)
Non-IUGR: 1 quarters (constitutionally small)
Risk factors
IUGR occurs when gas exchange and nutrient delivery
to the fetus are not sufficient
The process occur primariliy because of:
Maternal disease causing decreased oxygen-carrying
capacity
A dysfunctional oxygen delivery system secondary to
maternal vascular desease
Placental damage resulting from maternal disease
Many factors: fetoplacental fac tors and maternal
factors
Constitutionally small mother
Small women have smaller baby
Reduced intrauterine growth of mother reduced
intrauterine growth of her children
Environment more important than genetic contribution
Poor maternal weight gain and nutrition
Lack of weight gain in the second trimester associated with
fetal growth restriction
Social deprivation
Associated to lifestyle factors such as smoking, alcohol or other
substances abuse and poor nutrition
Fetal infections
Viral, bacterial, protozoon, and spirochaetal implicated on
fetal growth restriction
CMV direct cytolysis and loss functional cells
Rubella vascular deficiency
Another infection affect fetal growth : hepatitis A and B,
Listeriosis, TB, Syphilis, Toxoplasmosis and Congenital Malaria
Congenital malformations
More severe malformation more likely fetus to be small
Espescially with chromosomal abnormalities or serious
cardiovascular malformations
Chromosomal abnormalities
Autosomal trisomies related togrowth restriction
Trisomy 18, 13 and 21
Not seen in Turner or Klinefelter Syndrome
Trisomi 16
Patches of trisomy 16 confined placental mosaicism
placental insufficiency fetal growth restriction
Primary disorders of cartilage and bone
Osteogenesis imperfecta
Various chondrodystrophies
Chemical teratogens
Anticonvulsants (phenitoin, trimethadione)
Cigarette
Narcotics
Alcohol
Cocaine
Vascular disease
Chronic vascular disease especially when further complicated by
superimposed preeclampsia
Maternal anemia
Anemia does not cause growth restriction (in most
cases)
Except :
sickle cell disease
inherited anemia with serious maternal disease
deficient total blood volume early in pregnancy
Placental and cord abnormalities
Chronic partial placental separation
Extensive infarction
Chorioangioma
Marginal insertion of the cord
Velamentous insertion of the cord
Multiple fetuses
Two or more fetuses more likely complicated by
diminished growth of one or both fetuses compared
with normal singleton
Antiphospholipid antibody syndrome
Two classes of antiphospholipid antibodies :
Anticardiolipin antibodies
Lupus anticoagulant
Pathophysiological mechanism maternal platelet
aggregation & placental thrombosis
Extrauterine pregnancy
Fetus gestated outside uterus is usually growth
restricted
Also some maternal uterine malformations
Pathogenesis & Categories
Stage 2
First Stage Stage 3
Hyperplastic and
Hyperplactic Stage Hypertrophic Stage
Hypertrophic Stage
Symmetric Asymmetric
Pathogenesis & Categories
Symmetrical Growth Restriction
Growth inhibition during first stage undersized
fetus with fewer cells but normal size
Weight, head and length < 10th percentile
proportionally small
Condition associated include genetic
(constitutional, chromosomal and single gene
defect, deletion disorders and inborn error of
metabolism), congenital anomalies, intrauterine
infections, and therapeutic iradiation
Asymmetrical Growth Restriction
Growth inhibition during stage 2 and 3
decreased of cell size and fetal weight with less
effect on total cell number fetal length and fetal
head circumference
Implies fetus who is undernourished and
directing most of its energy to maintainaning
growth of vital organs such as brain and heart
at the expensive of the liver, muscle and fat
role of brain sparing effect (redistribution
mechanism)
Asymmetrical Growth Restriction
Normal head but small abdominal
circumference, scrawny limbs and thinned skin
Condition associated include uteroplacental
insufficiency (chronis hypertension or
preeclampsia), chronis renal disease, cyanotic
heart disease, hemoglobinopathies, placental
infarcs, abruptio placenta, multiple gestation,
velamentous insertion, cirmcumvallate placenta
and high altitude
Antepartum Complications
Stillbirth
Oligohydramnios
Intrapartum fetal
acidosis
Neonatal Complications