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Chapter Five
Mendels Laws
1. Principle of Segregation
Two alleles segregate randomly during
formation of gametes
2. Independent Assortment
Two genes will assort independently and
randomly from each other
Mendels Laws Not Perfect:
Shortly people began to notice that not all
traits are Mendelian
This means, they do NOT follow Mendels
laws
Was he just plain wrong?
H Hh
HH Expect to see 3:1 ratio
Hh hh
Instead see 100% dominant
h
1. Lethal Genotypes
Mendels Laws are still correct and still
being followed
Two alleles; one dominant and one recessive
Producing the 1:2:1 genotypic ratio
Only the phenotypic ratio that is changed
H h
H Hh
HH Expect to see 3:1 ratio
Hh hh
Instead see 100% dominant
h
2. Allelic Heterogeneity
More than two alleles of the same gene
ex Cystic Fibrosis has hundreds of alleles
possible on the same gene
Causes differences in phenotype depending
on which two alleles a person inherits
Still follow Mendels laws within one cross
Individual can only have two alleles (only
have two chromosomes)
One inherited from mother, one from father
3. Incomplete Dominance
One allele is not completely dominant over
the other
Causing the heterozygote to have a third,
different phenotype
ex Blending in flowers
Homo Dominant = red flowers
Homo recessive = white flowers
Heterozygotes = pink flowers
3. Incomplete Dominance
ex Blood Types
Type A = AA or Ao
Type B = BB or Bo
Type AB = AB (heterozygote)
Type O = oo (homozygous recessive)