Omega-3 Extraction

Group 10:
Ali Hamdani
Clarissa Merry
Gibranadhi
Maria
Syailendra Supit
 Background

General Extraction Process

OUTLINE Fatty Acid Extraction

Solvent Comparison

Conclusion
 Omega-3 fatty acids

Reduce Risk to Heart Disease

lower elevated triglyceride levels.

Prevent Rheumatoid arthritis

(EPA+DHA) can curb stiffness and joint
BACKGROUND pain.

Baby development
DHA is important for visual and
neurological development in infants.
DATA
General Extraction Process
 Process of extracting a Solute from a Feed by use of
Solvent to produce an Extract and a Raffinate
Extraction separates components based on their
Liquid-Liquid relative solubilities in two immiscible liquids
Extraction (LLE) LLE is used when the required solute from the feed
have an almost similar boiling point with the
carrier.
 Has lower process cost than distillation because no
heating cost is required
The two liquids must be immiscible or slightly
Liquid-Liquid miscible, thus allows them to form a dispersion
Extraction Separation is achieved when the substances
constituting the original solution is transferred to
the othe solution
 When the relative volatility is near unity.
When the formation of azeotropes limits the
Extraction is More degree of separation obtainable indistillation.
Preferable than
When heating must be avoided.
Distillation
When When the components to be separated are quite
different in nature.
 High Selectivity
High Recoverability
Has Density difference
Criteria of Difficult to react with the extract
Solute Non-corrosive
Non-Toxic
Economic
Multistage Extraction
Proses Process
Extract Solvent

Feed Raffinate

Feed (Carrier) : Contains solute

Single Stage
Batch
Extraction
Continuous
Two-stage
Extraction
Multistage Cross-flow Multistage Extraction

Extraction
Process

Counter-flow Multistage Extraction

OMEGA - 3 EXTRACTION
From Fish Oil
 Omega-3
Fish Oil Fatty Acid
Separation Enrichment

Fish Oil
Production
Purification Capsulation
and
Packaging
 Fish Oil
Separation
Conventional Method Degumming Neutralization Washing

Fish oil Drying Bleaching Filtration

Purification

Deodorization
 Urea Fractionation
Low-Temperature Fractional
Crystallization
Omega-3 Salt Solubility Methods
Fatty Acid Silica Gel Thin-Layer Chromatography
Enrichment Preparative-scale Gas Chromatography
Supercritical Fluid Technology
Enzymatic Hydrolysis Enrichment
Enzymatic Hydrolysis
Enrichment
Liquid-Liquid Extraction
Of Fatty Acids
 To observe the separation of fatty acid mixtures, Lyman C.
Craig (1951) developed an analytical method of
countercurrent distribution by LLE principle.
Countercurrent Distribution
Overview An analytical method
Mixtures are partitioned (distributed) between 2 immiscible
liquids based on the relative solubility
Uses separatory tunnel on the lab scale
 Lab Scale LLE :
Separatory Funnel
 The coefficient/ratio of partition is defined as the
concentration of an immiscible substance between 2
phases.

=

Fatty Acid
C1C18 Fatty acids have a sufficient partition ratio
Extraction to be separated analysed using the countercurrent
distribution method (Craig & Ahrens, 1951)
While long chain fatty acids (C10C18) has skewing
on the distribution as a result of non ideality
 The configuration of fatty acids strongly affected
by concentration and enviroment
Fatty Acid In each of the separation and phases of interest,
Extraction both the concentration and enviroment might
differ
 On neutral to high level of pH, fatty acids
molecules tends to associate creating micelles
A solvent is required to
Promote the association of fatty acids and the solvent
Solvent (has an identical chemical properties)
Prevent the association between fatty acids (lower pH)
Selection
Acetic acid
Carboxyl functional group
Acidic
Does not interfere with the analysis
 Solvent
Selection
 Partition Values
on Combinations
of Mixtures
Partition Values on
Combinations of
Mixtures

: Selectivity Ratio

=
/

Equilibrium (Ternary) Diagram
 160 cm3/s dari pelarut S digunkan
untuk memperlakukan 400 cm3/s
dari 10% larutan massa A dalam B
pada pabrik ekstraksi dengan tiga
stage dan aliran counter-current.
Berapakah komposisi dari rafinat
akhirnya? Latihan
Data kesetimbangannya adalah:
Kg A/kg B 0.05 0.10 0.15
Soal
Kg A/kg S 0.069 0.159 0.258
Densitas A = 1200 B = 1000 S = 800
(kg/m3)
 Konsentrasi pelarut = 160 cm3/s =
1.6 104 m3/s
Langkah 1:
Mencari Laju Alir Laju alir masssa pelarut = (1.6
Massa Pelarut 104 800) = 0.128 kg/s
 Konsentrasi Larutan = 400 cm3/s = 4
104 m3/s
Dengan komposisi A = m3/s dan B = (5
104 ) m3/s

Langkah 2: Laju Alir Massa A = 1200 kg/s

Mencari Laju Alir Laju Alir Massa B = (0.4 + 200) kg/s

Massa A dan B Konsentrasi larutan: 0.10 =
1200
0.4 + 200

Didapat: = 3.39 105 m3/s

Laju Alir Massa A = 0.041 kg/s
Laju Alir Massa B = 0.366 kg/s
 0.041
Rasio A/B pada feed = Xf = 0.366
=
Langkah 3: 0.112 kg/kg
Mencari Rasio Slope Kesetimbangan =
Feed dan Slope 0.366
Kesetimbangan
=
0.128
= 2.86
 Langkah 4:
Menggambar
Garis
Kesetimbangan
 Karena larutan murni yang ditambahkan,
Yn+1 = Y4 = 0 sebuah garis dengan
kemiringan 2.86 digambar sehingga dari
Langkah 5: Xf = 0.112 kg/kg sampai Y4 = 0 memberi
Mencari 3 stage.
Komposisi Akhir Saat Y4 = 0, Xn = X3 = 0.057 kg/kg
Rafinat Maka, komposisi akhir rafinat adalah
0.057 kg A/kg B
CONCLUSION
 Omega-3 is a very important nutrient needed by our
body.
Industries in Indonesia still rarely apply Omega-3
Enrichment process in Extraction process, due to
limitation in Capital and Human Resources.
Extraction is a very essential part for omega 3
enrichment.
Extraction is one of a separation process based on
affinity of each species.