KLASIFIKASI

NEOPLASMA
 PENDAHULUAN
Pembengkakan Abnormal
(Tumor)

Neoplasma Non Neoplasma

Maligna Benigna Kista Hipertrofi

Radang
 KOMPONEN NEOPLASMA
• Parenkim  sel tumor yang proliperatif  sifat
pertumbuhan
• Stroma  pendukung parenchym tumor
 KLASIFIKASI NEOPLASMA
1. Sifat Biologik Tumor
2. Sel atau Jaringan (histogenesis)
 BIOLOGIC BEHAVIOR OF NEOPLASM

1. Benign
2. Intermediate / Low-Grade Malignant
3. Malignant
 Benign Intermediate Maligna

Sifat Lambat Bervariasi Cepat

pertumbuhan

Tumbuh infiltratif Tidak/Expans Local Infiltratif

if
Metastasis Tidak ada Rendah / tidak ada Tinggi

Pengobatan Eksisi Eksisi Luas Eksisi luas,

pengangkatan
kelenjar regional,
kemoterapi
Angka Tinggi Cenderung residif Buruk, cenderung
kesembuhan residif dan metastasis
post operasi
 CELL OR TISSUE OF ORIGIN
(HISTOGENESIS)

Cell Of Origin

Totipoten Cells Pluripotent Cells Differianted Cells

 CELL OR TISSUE OF ORIGIN

• Neoplasma berasal dari sel totipotent

• Sel embryonal pluripotent
• Neoplasma sel yang berdiferensiasi
 TOTIPOTENT CELL

• A cell that is capable of differentiating (maturing) into

any cell type in the body
• the only totipotent cells in the body are the germ cells.
Primitive germ celss
 PLURIPOTENT CELLS

• Pluripotent cells can mature into several different cell

types
• These neoplasms are generally called embryomas or
blastomas
• Embryonic pluripotent cells are found only in the fetal
period and during the first few years of postnatal life.
The corresponding neoplasms usually occur in early
childhood and only rarely in adults.
 DIFFERENTIATED CELLS

• Differentiated, adult-type cells make up most of the

cells in the body in postnatal life. They show a restricted
potential for differentiation, as seen when they undergo
metaplasia. Most human neoplasms are derived from
differentiated cells.
1. Prostate 1. Breast
2. Lung 2. Colon &
3. Colon & rectum
rectum 3. Uterus