Documente Academic
Documente Profesional
Documente Cultură
Discovery
and
Design
Irene Lee
Case Western Reserve University
Cleveland, OH
©2004, Prentice Hall
A drug is any absorbed substance that changes or
enhances a physical or psychological function in the
body
Trimox® amoxicillin
antibiotic
®
Premarin conjugated
estrogens
hormone replacement
therapy
The goal of the medicinal chemist is to find compounds
that have potent effects on given diseases, with minimum
side effects
a drug with
an antibiotic
hypoglycemic activity
Molecular modification of promethazine leads to the
discovery of an antipsychotic drug
Drugs as Enzyme Inhibitors
• distribution
• binding
R
N
H2N N R'
a 2,4-diaminopyrimidine
potency = 0.8p – 7.34s – 8.14