STUDENT PROJECT 3

INNATE & ADAPTIVE IMMUNITY

MADE RICKY CATUR PURNAMA
1670121018
FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN
UNIVERSITAS WARMADEWA
2017
CONTENT

DEFINITION

HEMOSTASIS PROCESS

COAGULATION CASCADES

REFERENCES
 Definition

• Immunity refers to protection against infections, and immune system is the cells
and molecules collection that are responsible for defending the body from
pathogenic substances.
• Defense against microbes consists of two types of reactions :
• Innate immunity, is mediated by cells and proteins that are always present and
poised to fight against microbes.
• Adaptive immunity, that are stimulated by exposure to infectious agents and
increase in magnitude and defensive capabilities with each successive exposure
to a particular microbe.
 Innate Immunity

• Principal components :

1. Physical and chemical barriers : 2. Phagocytic Cells :

• Epithelial barrier - Neutrophils
• Gastric acids - Macrophages
• Cough and sneezing reflex - NK and dendritic cells
• Mucous
3. Blood Proteins :
- Complement system
- Inflammation mediators
Innate Immunity : Mechanism of Phagocytosis by Macrophage
Adaptive Immunity
• Types of Adaptive Immune system :

• Humoral Immunity, that is

mediated by molecules in the blood
mucosal secretions, called
antibodies, wich are produced by
cells called B lymphocyte.

• Cell-mediated Immunity, that is

mediated by T lymphocytes
eliminates the cells that infected by
such as bacterias or viruses
 B Lymphocytes
• B lymphocytes are the only cells capable of producing antibodies.
• They recognize extracellular soluble and cell surface antigens, and
they differentiate into antibody-secreting plasma cells that secretes
antibody for primary immune response.
• B lymphocytes also differentiate into memory cells wich are long-lived
and in charge if the secondary antigen exposure occurs to create
secondary immune response.
 T Lymphocytes
• T lymphocytes consist of functionally distinct population, wich are :
• Helper T Cells that secrete cytokines that stimulate proliferation and
differentiation of T cells themselves, macrophages, and other
leukocytes.
• Cytotoxic T Cells that kill cells producing foreign antigens, such as
cells infected by viruses and microbes.
• Regulatory T Cells to inhibit immune responses
Refferences
• Abbas, KA., Litchman, H., Pillai, S. 2015. Cellular And Molecular
Immunology. 8th ed. Philadelphia, USA
• Kumar, V., Abbas, KA., Aster, CJ. 2013. Robbins Basic Pathology. 9th
Ed. Canada, USA
• Silverthorn, DU. 2013. Human Physiology an Integrated Approach 6th
Ed. Pearson Education, San Fransisco, USA
• suksme