• Bibliografie selectiva:

- material de curs si LP – prezentat / postat pe site UMF

- Compendiul de specialitati medico-chirurgicale - Victor
Stoica, Viorel Scripcaru
- Priciples of Internal Medicine - Harrison

- Pneumologie – manual pentru studenti si rezidenti, Ed a

IIIa, Cristian Cojocaru, Elena Cojocaru, Traian Mihaescu,
EditDan, ISBN 978-973-8365-50-6, Iasi 2010
- Ghidul rezidentului – C Cojocaru, C Popa, Ed UMF -
biblioteca

1
• Tuberculoza
• Astm bronșic
• BPOC
• Infecții pulmonare - Pneumonia bacteriana
• Sindromul de apnee in somn
• Sarcoidoza
• Revarsate lichidiene pleurale
• Fumat
• Sindroame mediastinale
• Neoplasm bronhopulmonar
2
• Tuberculoza

– Istoric
– Epidemiologie
– Fiziopatologie
– Proprietatile M tuberculosis

3
ROBERT KOCH 1882
8
Sanatorium patients resting outside

10
13
 Istoria TB Timeline
1993: declin al cazurilor de TB
datorita cresterii finantarii si
1865: imbunatatirii controlului
Jean- 1884:
Antoine Primul
Villemin a sanatoriu 1943: Mijlocul anilor
dovedit pentru TB Streptomicina 1970 sanatoriile
natura fondat in este au fost inchise in
contagioasa SUA descoperita SUA

1840 1860 1880 1900 1920 1940 1960 1980 2000

1980: crestere
1882: neasteptata a
Robert Koch a descoperit 1943-1952: numarului de
M. tuberculosis Doua medicamente cazuri
noi: INH si PAS

Module 1 – Transmission and Pathogenesis of Tuberculosis 16

Estimated HIV prevalence in TB cases (2012)
22
26
 Transmiterea TB (5)

Module 1 – Transmission and Pathogenesis of Tuberculosis 27

Module 1 – Transmission and Pathogenesis of Tuberculosis 28
Small PM et al, N Engl J Med, 2001
 Patogeneza TB(2)
Infectia latenta cu M.t.

30
31
 bronchiole
2 blood vessel
tubercle bacilli

alveoli

32
3 bone
brain

lung

kidney

33
4 special
immune cells
form a barrier
shell (in this
example,
bacilli are
in the lungs)

34
5 shell breaks
down and
tubercle
bacilli escape
and multiply
(in this example,
TB disease
develops in
the lungs)

35
36
 Localizarea TB (1)

Bacilii pot ajunge in orice parte a corpului

Brain

Larynx
Lymph node
Bone Pleura
Lung
Kidney
Spine

37
Module 1 – Transmission and Pathogenesis of Tuberculosis 38
39